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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3h7rNAPAldo-keto reductase family 4 member C8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3h7rNAPAldo-keto reductase family 4 member C8/1.000
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.542
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.532
1x96NAPAldose reductase1.1.1.210.525
2j8tNAPAldose reductase1.1.1.210.524
1x98NAPAldose reductase1.1.1.210.521
1ah4NAPAldose reductase1.1.1.210.520
2hejNDPAldo-keto reductase family 1 member C211.1.10.519
1az2NAPAldose reductase1.1.1.210.517
2acqNAPAldose reductase1.1.1.210.516
2iq0NAPAldose reductase1.1.1.210.516
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.513
1adsNAPAldose reductase1.1.1.210.512
4dz5NAPAldo-keto reductase family 1 member C3/0.512
2pfhNDPAldose reductase1.1.1.210.510
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.506
3q67NAPAldose reductase1.1.1.210.506
1c9wNAPAldose reductase-related protein 2/0.505
1s1rNAPAldo-keto reductase family 1 member C3/0.505
2pf8NDPAldose reductase1.1.1.210.505
2acsNAPAldose reductase1.1.1.210.499
4pmjNAPPutative oxidoreductase/0.496
1z8aNAPAldose reductase1.1.1.210.494
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.494
2pevNDPAldose reductase1.1.1.210.493
3q65NAPAldose reductase1.1.1.210.489
4g5dNDPProstaglandin F synthase1.1.1.1880.488
3v36NAPAldose reductase1.1.1.210.485
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.482
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.481
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.480
2hdjNDPAldo-keto reductase family 1 member C2/0.479
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.479
4jtqNAPAldo-keto reductase family 1 member C2/0.478
4xo7NAPAldo-keto reductase family 1 member C2/0.477
2p5nNDPAldo-keto reductase family 1 member C211.1.10.474
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.470
4l1xNAPAldo-keto reductase family 1 member C2/0.462
5c7hNDPPutative oxidoreductase/0.459
3qkzNAPAldose reductase-related protein 11.1.1.210.455
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
1s1pNAPAldo-keto reductase family 1 member C3/0.452
4jq3NAPAldo-keto reductase family 1 member C2/0.451
3o3rNAPAldose reductase-related protein 11.1.1.210.450
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.450
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.448
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.448
2acuNAPAldose reductase1.1.1.210.447
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.445
3wczNAPAldo-keto reductase AKR2E4/0.444
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.442