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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ggcH26Hypoxanthine-guanine phosphoribosyltransferase2.4.2.8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ggcH26Hypoxanthine-guanine phosphoribosyltransferase2.4.2.81.000
3gep24HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.626
3ggj25HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.569
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.468
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.465
4n6hEJ4Delta-type opioid receptor/0.463
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.460
2yeiXQIHeat shock protein HSP 90-alpha/0.458
2vn0TDZCytochrome P450 2C8/0.457
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
1hmp5GPHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.452
1nzdUPGDNA beta-glucosyltransferase/0.448
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
3lqfNADGalactitol dehydrogenase/0.447
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.446
3zeiAWHO-acetylserine sulfhydrylase/0.446
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.446
1rfuADPPyridoxal kinase2.7.1.350.445
1nzfUPGDNA beta-glucosyltransferase/0.444
3iocA5DPantothenate synthetase6.3.2.10.443
1h74AGSHomoserine kinase2.7.1.390.442
2zsaADPPantothenate kinase2.7.1.330.442
3v2uATPProtein GAL3/0.442
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.441
2gesCOKPantothenate kinase2.7.1.330.440
3af3GCPPantothenate kinase2.7.1.330.440
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.440
3g6zA7TRenin3.4.23.150.440