sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.694 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.691 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.691 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.682 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.624 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.581 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.562 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.537 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.521 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.505 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.504 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.502 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.496 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.490 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.481 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.475 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.475 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.474 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.473 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.472 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.471 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.466 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.466 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.463 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.462 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.462 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.461 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.458 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.457 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.456 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.455 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.452 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2y4g | TIR | TamL | / | 0.452 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.451 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 5a3c | NAD | SIR2 family protein | / | 0.449 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.448 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3u9e | COA | Lmo1369 protein | / | 0.444 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.443 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.442 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.442 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.442 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.440 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.440 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.440 |