sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3dme | FAD | Putative conserved exported protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3dme | FAD | Putative conserved exported protein | / | 1.000 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.476 | |
| 5hxw | FAD | L-amino acid deaminase | / | 0.474 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.471 | |
| 5dp2 | NAP | CurF | / | 0.470 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.468 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.468 | |
| 4qec | NAP | ElxO | / | 0.468 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.466 | |
| 3awi | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 1.5 | 0.466 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.463 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.462 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.460 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.459 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.459 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.458 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.457 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.457 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.457 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2rgh | FAD | Alpha-Glycerophosphate Oxidase | / | 0.454 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.454 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1ng4 | FAD | Glycine oxidase | 1.4.3.19 | 0.453 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.453 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.452 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.452 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.451 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.451 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.451 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.451 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.449 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.449 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.447 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.447 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.446 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.446 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.445 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.445 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.445 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.444 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.444 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.444 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.444 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.444 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.443 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.443 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.443 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.443 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1gqt | ACP | Ribokinase | / | 0.442 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.442 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.442 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.441 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.441 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.441 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.441 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.441 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.440 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.440 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.440 |