scPDB - Distribution of Binding site Similarity values of 3cv6 entry / Site 2

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3cv6	HXS	Aldo-keto reductase family 1 member C21

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3cv6	HXS	Aldo-keto reductase family 1 member C21	/	1.000
4dbs	0HV	Aldo-keto reductase family 1 member C3	/	0.504
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.495
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.490
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.482
1u65	CP0	Acetylcholinesterase	3.1.1.7	0.477
3uzx	AOM	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.474
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.473
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.472
2vqo	TFG	Histone deacetylase 4	3.5.1.98	0.470
3tfu	PL8	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	2.6.1.62	0.469
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.469
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.468
3q9b	B3N	Acetylpolyamine amidohydrolase	/	0.467
1ihi	IU5	Aldo-keto reductase family 1 member C2	/	0.465
3hl0	NAD	Maleylacetate reductase	/	0.465
3n3z	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.465
4a81	DXC	Major pollen allergen Bet v 1-A	/	0.465
4jt9	1NS	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.465
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.464
4a95	9MT	Glycylpeptide N-tetradecanoyltransferase	/	0.464
2ipj	FFA	Aldo-keto reductase family 1 member C2	/	0.463
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.463
4c2z	646	Glycylpeptide N-tetradecanoyltransferase 1	/	0.463
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.462
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.462
4jtr	IZP	Aldo-keto reductase family 1 member C2	/	0.462
4bfs	ZVS	Pantothenate kinase	2.7.1.33	0.461
4fam	0SZ	Aldo-keto reductase family 1 member C3	/	0.460
2a0x	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.459
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.459
3ug8	IMN	Aldo-keto reductase family 1 member C3	/	0.459
1lke	DOG	Bilin-binding protein	/	0.458
3dyl	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.458
3pz3	PZ3	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.458
4ey6	GNT	Acetylcholinesterase	3.1.1.7	0.458
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.457
1zgc	A2E	Acetylcholinesterase	3.1.1.7	0.457
2gyu	HI6	Acetylcholinesterase	3.1.1.7	0.457
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.457
4jq3	ZOM	Aldo-keto reductase family 1 member C2	/	0.457
4jqa	ID8	Aldo-keto reductase family 1 member C2	/	0.457
1pqc	444	Oxysterols receptor LXR-beta	/	0.456
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.456
2xeg	CI9	Glutamate carboxypeptidase 2	3.4.17.21	0.456
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.455
2a58	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.455
2wwj	Y28	Lysine-specific demethylase 4A	/	0.455
4p9d	TMP	Deoxycytidylate deaminase	/	0.455
2vqq	TFG	Histone deacetylase 4	3.5.1.98	0.454
1pq6	965	Oxysterols receptor LXR-beta	/	0.453
2a2s	GSN	Glutathione S-transferase P	2.5.1.18	0.453
3uzx	AOX	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.453
4jt8	1NR	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.453
2a57	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.452
4arb	C57	Acetylcholinesterase	3.1.1.7	0.452
4dbw	511	Aldo-keto reductase family 1 member C3	/	0.452
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.451
2aj4	ANP	Galactokinase	2.7.1.6	0.451
2yg5	FAD	Putrescine oxidase	/	0.451
3f3y	4OA	Bile salt sulfotransferase	2.8.2.14	0.451
4c71	7RD	3-oxoacyl-ACP synthase	/	0.451
1ni1	HFP	Protein farnesyltransferase subunit beta	2.5.1.58	0.450
2gev	COK	Pantothenate kinase	2.7.1.33	0.450
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
4f1l	0RY	Poly [ADP-ribose] polymerase 14	2.4.2.30	0.450
4hyf	1AK	Tankyrase-2	2.4.2.30	0.450
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.449
2xei	ARK	Glutamate carboxypeptidase 2	3.4.17.21	0.449
3uzz	TES	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.449
1gpn	HUB	Acetylcholinesterase	3.1.1.7	0.448
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.448
2wnb	C5P	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	2.4.99.4	0.448
1amo	FMN	NADPH--cytochrome P450 reductase	/	0.447
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.447
3dyq	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
4g2l	0WL	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
4jsr	1NQ	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.447
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.446
1re0	AFB	ADP-ribosylation factor 1	/	0.446
1re0	AFB	ARF guanine-nucleotide exchange factor 1	/	0.446
3dy8	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.446
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.446
4a30	QMI	Glycylpeptide N-tetradecanoyltransferase	/	0.446
1d3p	BT3	Prothrombin	3.4.21.5	0.445
1nup	NMN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.445
1w6r	GNT	Acetylcholinesterase	3.1.1.7	0.445
1w87	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.445
2a59	LMZ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.445
3af1	GDP	Pantothenate kinase	2.7.1.33	0.445
3ihg	VAK	Aklavinone 12-hydroxylase RdmE	/	0.445
4psb	GA3	Cytokinin-specific binding protein	/	0.445
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.444
1sl9	CZH	Obelin	/	0.444
1ut6	A8N	Acetylcholinesterase	3.1.1.7	0.444
2v57	PRL	TetR family transcriptional regulator	/	0.444
3r8h	ZOM	Aldo-keto reductase family 1 member C3	/	0.444
3ugr	IMN	Aldo-keto reductase family 1 member C3	/	0.444
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.444
4j8t	DOG	Uncharacterized PhzA/B-like protein PA3332	/	0.444
3e33	ED7	Protein farnesyltransferase subunit beta	2.5.1.58	0.443
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.443
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.443
3tfj	THG	Dimethylsulfonioproprionate demethylase DmdA	2.1.1.269	0.443
4bub	ADP	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	/	0.443
4fal	0T0	Aldo-keto reductase family 1 member C3	/	0.443
4yfy	0FX	VioF	/	0.443
2ipi	AKY	Aclacinomycin-N/aclacinomycin-A oxidase	/	0.442
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.442
3cav	CI2	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.442
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.442
3sfy	3FY	Uncharacterized protein	/	0.442
4b2g	V1N	Uncharacterized protein	/	0.442
4jtr	IBP	Aldo-keto reductase family 1 member C2	/	0.442
4mlp	2CX	Cryptochrome-2	/	0.442
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.441
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.441
1zkn	IBM	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
3c1o	NAP	Eugenol synthase	/	0.441
3mjr	AC2	Deoxycytidine kinase	2.7.1.74	0.441
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.441
4bfw	ZVW	Pantothenate kinase	2.7.1.33	0.441
4gh6	LUO	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.441
4hhz	15S	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.441
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.440
1lnm	DTX	Bilin-binding protein	/	0.440
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.440
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.440
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.440
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.440
3qeo	LLT	Deoxycytidine kinase	2.7.1.74	0.440