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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.184

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1841.000
1n5dNDPCarbonyl reductase [NADPH] 1/0.599
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.567
4hwkNAPSepiapterin reductase1.1.1.1530.547
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.543
5idwNAPShort-chain dehydrogenase/reductase SDR/0.542
4j7uNAPSepiapterin reductase1.1.1.1530.540
1snyNAPLD36273p/0.537
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.534
4j7xNAPSepiapterin reductase1.1.1.1530.529
1ae1NAPTropinone reductase 1/0.525
1x7gNAPPutative ketoacyl reductase1.3.10.525
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.521
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.519
1pr9NAPL-xylulose reductase1.1.1.100.515
3gy0NAPNAD(P)-dependent oxidoreductase/0.512
1oaaNAPSepiapterin reductase1.1.1.1530.511
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.508
1wntNAPL-xylulose reductase1.1.1.100.507
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.506
3p19NDPPutative blue fluorescent protein/0.506
1w4zNAPPutative ketoacyl reductase1.3.10.503
2bd0NAPSepiapterin reductase/0.503
2dteNAIGlucose 1-dehydrogenase related protein/0.503
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.502
4qecNAPElxO/0.502
1ipeNDPTropinone reductase 21.1.1.2360.501
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.501
1xg5NAPDehydrogenase/reductase SDR family member 11/0.500
1xkqNDPUncharacterized protein/0.499
2yutNAPPutative short-chain oxidoreductase/0.497
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.495
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.493
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.491
3toxNAPPutative oxidoreductase/0.489
1x7hNDPPutative ketoacyl reductase1.3.10.487
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.486
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.486
4qedNAPElxO/0.486
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.484
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.484
2wsbNADGalactitol dehydrogenase/0.483
4bmvNAPShort-chain dehydrogenase/0.483
4dc1NDPPutative ketoacyl reductase1.3.10.483
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.483
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.482
3lqfNADGalactitol dehydrogenase/0.482
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.482
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.482
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.481
3f1kNAPUncharacterized oxidoreductase YciK10.479
5jlaNADPutative short-chain dehydrogenase/reductase/0.479
3d3wNAPL-xylulose reductase1.1.1.100.478
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.474
3qrwNDPPutative ketoacyl reductase1.3.10.472
3tn7NJPShort-chain alcohol dehydrogenase/0.470
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.470
3l77NJPShort-chain alcohol dehydrogenase/0.469
2wdzNADGalactitol dehydrogenase/0.468
4gh5NADShort-chain dehydrogenase/reductase SDR/0.467
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.463
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.462
1rwbNADGlucose 1-dehydrogenase1.1.1.470.461
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
2jahNDPClavaldehyde dehydrogenase/0.460
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.460
3w8eNAD3-hydroxybutyrate dehydrogenase/0.459
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.457
1mg5NAIAlcohol dehydrogenase1.1.1.10.457
3sjuNDPKeto reductase/0.455
4yaiNAIC alpha-dehydrogenase/0.454
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
1i3lNADUDP-glucose 4-epimerase/0.451
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.451
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.451
3rj9NADAlcohol dehydrogenase1.1.1.10.451
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.450
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.450
3w8dNAD3-hydroxybutyrate dehydrogenase/0.450
1iy8NADLevodione reductase/0.449
3w8fNAD3-hydroxybutyrate dehydrogenase/0.449
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.448
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.447
3ak4NADNADH-dependent quinuclidinone reductase/0.445
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.445
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.444
5dcyNAPIridoid synthase1.3.1.990.443
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.442
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.442
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.442
1g6kNADGlucose 1-dehydrogenase1.1.1.470.441
4jbiNDPAlcohol dehydrogenase (Zinc)/0.441
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.440