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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.582
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.572
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.543
2rabFADGlutathione amide reductase/0.542
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.538
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.516
1geuFADGlutathione reductase1.8.1.70.494
1grbFADGlutathione reductase, mitochondrial1.8.1.70.484
3djgFADGlutathione reductase, mitochondrial1.8.1.70.481
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.481
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.480
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.474
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.473
1getFADGlutathione reductase1.8.1.70.471
1gerFADGlutathione reductase1.8.1.70.466
1greFADGlutathione reductase, mitochondrial1.8.1.70.466
1grhFADGlutathione reductase, mitochondrial1.8.1.70.462
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.462
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.459
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.454
3djjFADGlutathione reductase, mitochondrial1.8.1.70.454
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.440