scPDB - Distribution of Binding site Similarity values of 2zth entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2zth	SAM	Catechol O-methyltransferase	2.1.1.6

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2zth	SAM	Catechol O-methyltransferase	2.1.1.6	1.000
3nwb	659	Catechol O-methyltransferase	2.1.1.6	0.538
3hvi	619	Catechol O-methyltransferase	2.1.1.6	0.528
3oe4	610	Catechol O-methyltransferase	2.1.1.6	0.515
1jr4	CL4	Catechol O-methyltransferase	2.1.1.6	0.507
3hvk	719	Catechol O-methyltransferase	2.1.1.6	0.503
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.493
3p3z	P3Z	Putative cytochrome P450	/	0.485
1hpz	AAP	Gag-Pol polyprotein	2.7.7.49	0.476
4rts	SAM	DNA adenine methylase	2.1.1.72	0.476
3pll	F06	Endothiapepsin	3.4.23.22	0.472
4blw	SAH	Ribosomal RNA large subunit methyltransferase J	/	0.471
2qta	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.469
4ia7	BIV	Vitamin D3 receptor A	/	0.469
2dv7	SAH	Diphthine synthase	/	0.468
4gbe	SAH	DNA adenine methylase	2.1.1.72	0.467
3hf6	LX0	Tryptophan 5-hydroxylase 1	1.14.16.4	0.466
3ssm	SAH	Mycinamicin VI 2''-O-methyltransferase	/	0.466
2g28	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.465
3bgv	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.464
3p9k	SAH	Caffeic acid O-methyltransferase	/	0.462
2iea	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.461
3t7s	SAM	Uncharacterized protein	/	0.461
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.461
4rtn	SAH	DNA adenine methylase	2.1.1.72	0.461
4ia3	BIV	Vitamin D3 receptor A	/	0.458
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.457
2d1y	NAD	Oxidoreductase, short-chain dehydrogenase/reductase family	/	0.457
3h03	UBP	Glutamate receptor 2	/	0.457
3nj0	PYV	Abscisic acid receptor PYL2	/	0.457
4rtm	SAM	DNA adenine methylase	2.1.1.72	0.457
1suo	CPZ	Cytochrome P450 2B4	1.14.14.1	0.456
3grv	ADN	Probable ribosomal RNA small subunit methyltransferase A	/	0.455
4jq8	KJ8	Epidermal growth factor receptor	2.7.10.1	0.455
2e07	SAH	Diphthine synthase	/	0.454
2g1p	SAH	DNA adenine methylase	2.1.1.72	0.454
1hnv	TBO	Gag-Pol polyprotein	2.7.7.49	0.453
3v97	SAH	Ribosomal RNA large subunit methyltransferase K/L	2.1.1.173	0.453
4eoi	1RO	Cyclin-dependent kinase 2	2.7.11.22	0.453
5jtb	ZMA	Adenosine receptor A2a	/	0.453
3kpj	SAH	Phenylethanolamine N-methyltransferase	2.1.1.28	0.452
3njo	PYV	Abscisic acid receptor PYR1	/	0.452
5ah5	LSS	Leucine--tRNA ligase	/	0.452
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.451
4ia1	BIV	Vitamin D3 receptor A	/	0.451
1c1b	GCA	Gag-Pol polyprotein	2.7.7.49	0.450
1jq3	AAT	Polyamine aminopropyltransferase	/	0.450
2jed	LG8	Protein kinase C theta type	2.7.11.13	0.450
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.450
1o97	FAD	Electron transfer flavoprotein subunit alpha	/	0.449
1syn	F89	Thymidylate synthase	/	0.449
1ve3	SAM	Uncharacterized protein	/	0.449
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.449
2ph5	NAD	Homospermidine synthase	/	0.449
3ox4	NAD	Alcohol dehydrogenase 2	1.1.1.1	0.449
3r02	UNM	Serine/threonine-protein kinase pim-1	2.7.11.1	0.449
4rtk	SAH	DNA adenine methylase	2.1.1.72	0.449
3v94	WYQ	Phosphodiesterase	/	0.447
1fxs	NAP	GDP-L-fucose synthase	/	0.446
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.446
2yyu	C5P	Orotidine 5'-phosphate decarboxylase	/	0.446
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.446
4at3	LTI	BDNF/NT-3 growth factors receptor	2.7.10.1	0.446
4jq7	KJQ	Epidermal growth factor receptor	2.7.10.1	0.446
4kdr	SAH	Ubiquinone biosynthesis O-methyltransferase	/	0.446
5f8e	SAH	Possible transcriptional regulatory protein	/	0.446
1hqu	HBY	Gag-Pol polyprotein	2.7.7.49	0.445
2c9z	QUE	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.445
2p6l	SAH	Diphthine synthase	/	0.445
3zku	HCV	Isopenicillin N synthase	1.21.3.1	0.445
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.445
2dv4	SAH	Diphthine synthase	/	0.444
3w0y	DS4	Vitamin D3 receptor	/	0.444
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.444
1yi4	ADN	Serine/threonine-protein kinase pim-1	2.7.11.1	0.443
2c31	ADP	Oxalyl-CoA decarboxylase	4.1.1.8	0.443
2emu	SAH	Diphthine synthase	/	0.443
3c1t	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.443
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.443
3l9l	L9L	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.443
3sso	SAH	Mycinamicin VI 2''-O-methyltransferase	/	0.443
5bp9	SAH	Putative methyltransferase protein	/	0.443
1crb	RTL	Retinol-binding protein 1	/	0.442
1nbi	SAM	Glycine N-methyltransferase	2.1.1.20	0.442
2b36	5PP	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.442
3p2e	SAH	16S rRNA (adenine(1408)-N(1))-methyltransferase	2.1.1.180	0.442
3u8h	BHP	Phospholipase A2, membrane associated	/	0.442
5uvi	ZMA	Adenosine receptor A2a	/	0.442
1bsv	NDP	GDP-L-fucose synthase	/	0.441
2np7	NEA	Modification methylase TaqI	2.1.1.72	0.441
2pwy	SAH	tRNA (adenine(58)-N(1))-methyltransferase TrmI	2.1.1.220	0.441
2xc3	RT8	Steroid C26-monooxygenase	1.14.13.141	0.441
3gc9	B45	Mitogen-activated protein kinase 11	2.7.11.24	0.441
3pce	3HP	Protocatechuate 3,4-dioxygenase alpha chain	1.13.11.3	0.441
3pce	3HP	Protocatechuate 3,4-dioxygenase beta chain	1.13.11.3	0.441
4pnr	G18	Tankyrase-2	2.4.2.30	0.441
4z28	BTN	Hoefavidin	/	0.441
5bp7	SAH	SAM-dependent methyltransferase	/	0.441
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.440
1o5r	FR9	Adenosine deaminase	3.5.4.4	0.440