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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zi224UProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zi224UProthrombin3.4.21.51.000
2zfq45UProthrombin3.4.21.50.777
2znk31UProthrombin3.4.21.50.766
4ax9N5NProthrombin3.4.21.50.739
2zda32UProthrombin3.4.21.50.736
2zc922UProthrombin3.4.21.50.730
2zdv37UProthrombin3.4.21.50.730
2zfr46UProthrombin3.4.21.50.725
3biu10UProthrombin3.4.21.50.722
2zgx29UProthrombin3.4.21.50.712
2zhf49UProthrombin3.4.21.50.712
2zg050UProthrombin3.4.21.50.708
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.700
2zhe13UProthrombin3.4.21.50.698
1d6w00RProthrombin3.4.21.50.676
1d4pBPPProthrombin3.4.21.50.674
1mueCDDProthrombin3.4.21.50.674
2zff53UProthrombin3.4.21.50.672
1ypeUIPProthrombin3.4.21.50.670
3eq02TSProthrombin3.4.21.50.669
1ypgUIRProthrombin3.4.21.50.665
2v3oI26Prothrombin3.4.21.50.664
2jh5895Prothrombin3.4.21.50.663
3c1kT15Prothrombin3.4.21.50.659
1mu6CDAProthrombin3.4.21.50.658
1t4u81AProthrombin3.4.21.50.657
3biv11UProthrombin3.4.21.50.657
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.657
1t4v14AProthrombin3.4.21.50.656
1k21IGNProthrombin3.4.21.50.655
1yplRA8Prothrombin3.4.21.50.654
2anmCDOProthrombin3.4.21.50.652
2r2mI50Prothrombin3.4.21.50.649
1z71L17Prothrombin3.4.21.50.647
3dux64UProthrombin3.4.21.50.644
4bamMM9Prothrombin3.4.21.50.643
2zhq27UProthrombin3.4.21.50.640
1c4uIH1Prothrombin3.4.21.50.639
1ypjUIBProthrombin3.4.21.50.639
4bakM67Prothrombin3.4.21.50.638
1ta6177Prothrombin3.4.21.50.637
2bdyUNBProthrombin3.4.21.50.637
2ziq26UProthrombin3.4.21.50.635
1zgv501Prothrombin3.4.21.50.634
1zrb062Prothrombin3.4.21.50.634
1afeALZProthrombin3.4.21.50.631
2zgb21UProthrombin3.4.21.50.630
1ypkCCRProthrombin3.4.21.50.623
4n3l2FNProthrombin3.4.21.50.623
1zgi382Prothrombin3.4.21.50.622
1xm1GAHProthrombin3.4.21.50.621
2jh6894Prothrombin3.4.21.50.618
1jwtBLIProthrombin3.4.21.50.617
3qwc98PProthrombin3.4.21.50.617
2uuk897Prothrombin3.4.21.50.616
1c4yIH3Prothrombin3.4.21.50.615
4lxb7R9Prothrombin3.4.21.50.615
1ae8AZLProthrombin3.4.21.50.614
4ayy9MXProthrombin3.4.21.50.613
2pksG44Prothrombin3.4.21.50.611
2cf9348Prothrombin3.4.21.50.608
2zfp19UProthrombin3.4.21.50.607
1nm6L86Prothrombin3.4.21.50.605
1sb1165Prothrombin3.4.21.50.605
3c27DKKProthrombin3.4.21.50.605
3dhk23UProthrombin3.4.21.50.603
1ypmRA4Prothrombin3.4.21.50.601
2zf051UProthrombin3.4.21.50.601
1vzqSHYProthrombin3.4.21.50.600
2jh0701Prothrombin3.4.21.50.600
1d3dBZTProthrombin3.4.21.50.599
2gdeSN3Prothrombin3.4.21.50.594
2bvs2CEProthrombin3.4.21.50.592
1d9i00PProthrombin3.4.21.50.590
4banM6SProthrombin3.4.21.50.588
1nzq162Prothrombin3.4.21.50.585
4e7r0NWProthrombin3.4.21.50.583
1oytFSNProthrombin3.4.21.50.582
3p1799PProthrombin3.4.21.50.582
4baqM4ZProthrombin3.4.21.50.580
4az29MUProthrombin3.4.21.50.579
1a4wQWEProthrombin3.4.21.50.573
1k22MELProthrombin3.4.21.50.571
3egkM18Prothrombin3.4.21.50.569
3qto10PProthrombin3.4.21.50.569
2zhw12UProthrombin3.4.21.50.563
1d3pBT3Prothrombin3.4.21.50.562
4ayv9MQProthrombin3.4.21.50.559
2cn0F25Prothrombin3.4.21.50.557
4baoMVFProthrombin3.4.21.50.556
2cf8ESHProthrombin3.4.21.50.552
2uuj896Prothrombin3.4.21.50.543
3utu1TSProthrombin3.4.21.50.536
4bahMELProthrombin3.4.21.50.533
1riwOSCProthrombin3.4.21.50.532
1mu8CDBProthrombin3.4.21.50.530
1uvsI11Prothrombin3.4.21.50.529
5cmx0G6Prothrombin3.4.21.50.526
2v3hI25Prothrombin3.4.21.50.521
2bxtC2DProthrombin3.4.21.50.518
1o0d163Prothrombin3.4.21.50.517
4rn615UProthrombin3.4.21.50.515
1w7gMIUProthrombin3.4.21.50.510
3qtv06PProthrombin3.4.21.50.508
4hfp15UProthrombin3.4.21.50.505
3f6891UProthrombin3.4.21.50.494
1c4vIH2Prothrombin3.4.21.50.491
2a2xNA9Prothrombin3.4.21.50.482
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.478
1ktsC24Prothrombin3.4.21.50.469
1ta2176Prothrombin3.4.21.50.469
1umaIN2Prothrombin3.4.21.50.469
4loy6XSProthrombin3.4.21.50.468
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.466
1ghv120Prothrombin3.4.21.50.459
1bcuPRLProthrombin3.4.21.50.457
2iqgF2IBeta-secretase 13.4.23.460.451
4q71FADBifunctional protein PutA/0.451
4dpi0N1Beta-secretase 13.4.23.460.450
2wf3ZY3Beta-secretase 13.4.23.460.449
4kbyC2EStimulator of interferon genes protein/0.449
1c5nESIProthrombin3.4.21.50.448
1xs7MMIBeta-secretase 13.4.23.460.448
1gj4132Prothrombin3.4.21.50.446
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.446
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.446
1c7oPPGHemolysin/0.443
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.442
3adaNADSubunit alpha of sarocosine oxidase/0.442
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
2wf1ZY1Beta-secretase 13.4.23.460.441
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.440