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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zhq27UProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zhq27UProthrombin3.4.21.51.000
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.761
2zgb21UProthrombin3.4.21.50.753
2zgx29UProthrombin3.4.21.50.747
2zhf49UProthrombin3.4.21.50.742
3eq02TSProthrombin3.4.21.50.727
2zhe13UProthrombin3.4.21.50.718
4bahMELProthrombin3.4.21.50.714
2zdv37UProthrombin3.4.21.50.709
2zff53UProthrombin3.4.21.50.709
2znk31UProthrombin3.4.21.50.709
3biu10UProthrombin3.4.21.50.709
2zfr46UProthrombin3.4.21.50.698
2r2mI50Prothrombin3.4.21.50.697
2zda32UProthrombin3.4.21.50.697
4baoMVFProthrombin3.4.21.50.693
3qto10PProthrombin3.4.21.50.684
1ypmRA4Prothrombin3.4.21.50.682
2zc922UProthrombin3.4.21.50.681
2bdyUNBProthrombin3.4.21.50.679
3dux64UProthrombin3.4.21.50.679
3p1799PProthrombin3.4.21.50.674
1d3dBZTProthrombin3.4.21.50.673
2pksG44Prothrombin3.4.21.50.669
3qtv06PProthrombin3.4.21.50.669
2zg050UProthrombin3.4.21.50.664
2zi224UProthrombin3.4.21.50.661
1c4uIH1Prothrombin3.4.21.50.656
2anmCDOProthrombin3.4.21.50.654
2jh5895Prothrombin3.4.21.50.654
2v3oI26Prothrombin3.4.21.50.642
4ax9N5NProthrombin3.4.21.50.642
2zhw12UProthrombin3.4.21.50.641
1sb1165Prothrombin3.4.21.50.638
2zfp19UProthrombin3.4.21.50.638
3qwc98PProthrombin3.4.21.50.637
1nm6L86Prothrombin3.4.21.50.636
4bakM67Prothrombin3.4.21.50.635
2cf8ESHProthrombin3.4.21.50.634
1d4pBPPProthrombin3.4.21.50.632
1d3pBT3Prothrombin3.4.21.50.629
1d9i00PProthrombin3.4.21.50.629
2uuk897Prothrombin3.4.21.50.625
2zf051UProthrombin3.4.21.50.625
4bamMM9Prothrombin3.4.21.50.621
1jwtBLIProthrombin3.4.21.50.618
2v3hI25Prothrombin3.4.21.50.618
3c1kT15Prothrombin3.4.21.50.618
2zfq45UProthrombin3.4.21.50.617
3c27DKKProthrombin3.4.21.50.615
1ypeUIPProthrombin3.4.21.50.613
2jh0701Prothrombin3.4.21.50.612
1ypjUIBProthrombin3.4.21.50.609
4ayy9MXProthrombin3.4.21.50.609
1ta6177Prothrombin3.4.21.50.606
1ypkCCRProthrombin3.4.21.50.606
2cn0F25Prothrombin3.4.21.50.606
1xm1GAHProthrombin3.4.21.50.605
1ypgUIRProthrombin3.4.21.50.605
1yplRA8Prothrombin3.4.21.50.605
1k22MELProthrombin3.4.21.50.602
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.602
4n3l2FNProthrombin3.4.21.50.601
1zgi382Prothrombin3.4.21.50.599
3biv11UProthrombin3.4.21.50.599
1t4u81AProthrombin3.4.21.50.598
1z71L17Prothrombin3.4.21.50.598
3utu1TSProthrombin3.4.21.50.598
2bvs2CEProthrombin3.4.21.50.596
2jh6894Prothrombin3.4.21.50.596
1c4yIH3Prothrombin3.4.21.50.595
1k21IGNProthrombin3.4.21.50.590
1oytFSNProthrombin3.4.21.50.586
3dhk23UProthrombin3.4.21.50.586
1d6w00RProthrombin3.4.21.50.585
4banM6SProthrombin3.4.21.50.585
4lxb7R9Prothrombin3.4.21.50.585
1mueCDDProthrombin3.4.21.50.584
1t4v14AProthrombin3.4.21.50.581
2uuj896Prothrombin3.4.21.50.580
1mu6CDAProthrombin3.4.21.50.579
1ae8AZLProthrombin3.4.21.50.578
2cf9348Prothrombin3.4.21.50.572
4az29MUProthrombin3.4.21.50.569
1zgv501Prothrombin3.4.21.50.568
1a4wQWEProthrombin3.4.21.50.567
1afeALZProthrombin3.4.21.50.565
4baqM4ZProthrombin3.4.21.50.563
1c4vIH2Prothrombin3.4.21.50.560
4rn615UProthrombin3.4.21.50.560
1nzq162Prothrombin3.4.21.50.558
1vzqSHYProthrombin3.4.21.50.558
1zrb062Prothrombin3.4.21.50.558
2ziq26UProthrombin3.4.21.50.553
1riwOSCProthrombin3.4.21.50.550
1ghv120Prothrombin3.4.21.50.545
2bxtC2DProthrombin3.4.21.50.545
2gdeSN3Prothrombin3.4.21.50.538
3f6891UProthrombin3.4.21.50.534
1w7gMIUProthrombin3.4.21.50.533
5cmx0G6Prothrombin3.4.21.50.532
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.528
1mu8CDBProthrombin3.4.21.50.515
4ayv9MQProthrombin3.4.21.50.504
4hfp15UProthrombin3.4.21.50.503
1o0d163Prothrombin3.4.21.50.502
3egkM18Prothrombin3.4.21.50.496
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.496
1uvsI11Prothrombin3.4.21.50.490
2a2xNA9Prothrombin3.4.21.50.488
1ktsC24Prothrombin3.4.21.50.487
4loy6XSProthrombin3.4.21.50.471
2ignFADPyranose 2-oxidase/0.467
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.467
1c5nESIProthrombin3.4.21.50.462
4bttVYRCoagulation factor X3.4.21.60.459
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.457
1ta2176Prothrombin3.4.21.50.457
3q7fED2Uncharacterized protein/0.457
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.454
1umaIN2Prothrombin3.4.21.50.452
3oqkS52Renin3.4.23.150.452
1bcuPRLProthrombin3.4.21.50.451
3bg7FADPyranose 2-oxidase/0.449
4q71FADBifunctional protein PutA/0.449
1j9zFADNADPH--cytochrome P450 reductase/0.447
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.447
4bfxZVXPantothenate kinase2.7.1.330.447
4xguADPPutative pachytene checkpoint protein 2/0.447
1fmlRTLRetinol dehydratase/0.443
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
2wu4HBPAcetylcholinesterase3.1.1.70.442
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.442
3oqfS51Renin3.4.23.150.442
4kbyC2EStimulator of interferon genes protein/0.442
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.441
3eksCY9Actin-5C/0.440
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.440