scPDB - Distribution of Binding site Similarity values of 2zf4 entry / Site 9

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2zf4	PPY	Uncharacterized protein

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2zf4	PPY	Uncharacterized protein	/	1.000
3jwt	H4B	Nitric oxide synthase, brain	1.14.13.39	0.511
3ufs	H4B	Nitric oxide synthase, brain	1.14.13.39	0.506
3pne	H4B	Nitric oxide synthase, brain	1.14.13.39	0.503
3nlq	H4B	Nitric oxide synthase, brain	1.14.13.39	0.497
4imw	H4B	Nitric oxide synthase, brain	1.14.13.39	0.497
3ufv	H4B	Nitric oxide synthase, brain	1.14.13.39	0.493
3jt7	H4B	Nitric oxide synthase, brain	1.14.13.39	0.492
3nnz	H4B	Nitric oxide synthase, brain	1.14.13.39	0.491
1akb	PPD	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.490
3jt5	H4B	Nitric oxide synthase, brain	1.14.13.39	0.489
3tym	H4B	Nitric oxide synthase, brain	1.14.13.39	0.487
3gy9	COA	GCN5-related N-acetyltransferase	/	0.486
3ufw	H4B	Nitric oxide synthase, brain	1.14.13.39	0.486
1akc	PPE	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.485
3nly	H4B	Nitric oxide synthase, brain	1.14.13.39	0.484
3nny	H4B	Nitric oxide synthase, brain	1.14.13.39	0.484
4ead	0NP	Thymidine phosphorylase	2.4.2.4	0.481
3svq	H4B	Nitric oxide synthase, brain	1.14.13.39	0.480
5agp	H4B	Nitric oxide synthase, brain	1.14.13.39	0.479
3nos	H4B	Nitric oxide synthase, endothelial	1.14.13.39	0.478
3q9a	H4B	Nitric oxide synthase, brain	1.14.13.39	0.478
3rqk	H4B	Nitric oxide synthase, brain	1.14.13.39	0.477
3rql	H4B	Nitric oxide synthase, brain	1.14.13.39	0.477
3png	H4B	Nitric oxide synthase, brain	1.14.13.39	0.476
3uhm	RFN	UDP-3-O-acyl-N-acetylglucosamine deacetylase	/	0.476
3svp	H4B	Nitric oxide synthase, brain	1.14.13.39	0.474
3jta	H4B	Nitric oxide synthase, brain	1.14.13.39	0.473
3pnf	H4B	Nitric oxide synthase, brain	1.14.13.39	0.473
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.473
2hx4	H4B	Nitric oxide synthase, brain	1.14.13.39	0.472
2idx	ATP	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial	2.5.1.17	0.472
2yx6	ADP	Uncharacterized protein	/	0.472
2g6j	7AP	Nitric oxide synthase, brain	1.14.13.39	0.471
3b3o	H4B	Nitric oxide synthase, brain	1.14.13.39	0.471
3jt9	H4B	Nitric oxide synthase, brain	1.14.13.39	0.471
3tyd	XHP	Dihydropteroate synthase	/	0.470
4fvx	H4B	Nitric oxide synthase, brain	1.14.13.39	0.470
4lux	H4B	Nitric oxide synthase, brain	1.14.13.39	0.469
4qbi	AP5	Adenylate kinase	/	0.469
1pnq	NDP	NAD(P) transhydrogenase subunit beta	1.6.1.2	0.468
3tyl	H4B	Nitric oxide synthase, brain	1.14.13.39	0.468
4idg	NAD	Putative UDP-glucose 4-epimerase	/	0.468
4jsh	H4B	Nitric oxide synthase, brain	1.14.13.39	0.468
3rqj	H4B	Nitric oxide synthase, brain	1.14.13.39	0.467
4bfw	ZVW	Pantothenate kinase	2.7.1.33	0.466
1zzu	H4B	Nitric oxide synthase, brain	1.14.13.39	0.465
1zzq	H4B	Nitric oxide synthase, brain	1.14.13.39	0.464
3n5z	H4B	Nitric oxide synthase, brain	1.14.13.39	0.464
2re8	GSU	Glutamine--tRNA ligase	6.1.1.18	0.462
2w98	P1Z	Prostaglandin reductase 2	1.3.1.48	0.462
3p8i	FMN	Pentaerythritol tetranitrate reductase	/	0.461
3zbs	OVE	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.461
4imt	H4B	Nitric oxide synthase, brain	1.14.13.39	0.461
4ys0	ADP	Protein translocase subunit SecA	/	0.461
3lfm	3DT	Alpha-ketoglutarate-dependent dioxygenase FTO	/	0.460
3ufu	H4B	Nitric oxide synthase, brain	1.14.13.39	0.460
3v3n	MIY	TetX family tetracycline inactivation enzyme	/	0.460
3uov	FAD	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.458
4jsi	H4B	Nitric oxide synthase, brain	1.14.13.39	0.458
4kq2	U5P	Glycogen [starch] synthase isoform 2	2.4.1.11	0.458
5dp2	NAP	CurF	/	0.458
1dp2	LPB	Thiosulfate sulfurtransferase	/	0.457
2rgx	AP5	Adenylate kinase	/	0.457
4ol0	GTP	GTP-binding nuclear protein Ran	/	0.457
4qbh	AP5	Adenylate kinase	/	0.457
4g0k	0VS	Glutathionyl-hydroquinone reductase YqjG	1.8	0.456
1rs6	H4B	Nitric oxide synthase, brain	1.14.13.39	0.455
2g0n	GDP	Ras-related C3 botulinum toxin substrate 3	/	0.455
2xf3	J01	Uncharacterized protein	/	0.455
4bqw	QNM	Egl nine homolog 1	/	0.455
2bxo	OPB	Serum albumin	/	0.454
3q99	H4B	Nitric oxide synthase, brain	1.14.13.39	0.454
1h50	FMN	Pentaerythritol tetranitrate reductase	/	0.453
1hk3	T44	Serum albumin	/	0.453
4cx3	H4B	Nitric oxide synthase, brain	1.14.13.39	0.453
2rd2	QSI	Glutamine--tRNA ligase	6.1.1.18	0.452
3b3n	H4B	Nitric oxide synthase, brain	1.14.13.39	0.452
3nlo	H4B	Nitric oxide synthase, brain	1.14.13.39	0.452
4ivr	N50	Thymidine kinase	/	0.452
2oo7	AP5	Adenylate kinase	/	0.451
3jwv	H4B	Nitric oxide synthase, brain	1.14.13.39	0.451
3jt8	H4B	Nitric oxide synthase, brain	1.14.13.39	0.450
3nlp	H4B	Nitric oxide synthase, brain	1.14.13.39	0.450
1vyr	FMN	Pentaerythritol tetranitrate reductase	/	0.449
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.449
2xeg	CI9	Glutamate carboxypeptidase 2	3.4.17.21	0.449
2poq	ISD	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	1.3.1.20	0.448
3e6e	DCS	Alanine racemase	/	0.448
1om5	H4B	Nitric oxide synthase, brain	1.14.13.39	0.447
1u1d	181	Uridine phosphorylase	2.4.2.3	0.447
2xvv	9DN	Serum albumin	/	0.447
4qak	2AM	RNA 2',3'-cyclic phosphodiesterase	/	0.447
3hu1	AGS	Transitional endoplasmic reticulum ATPase	3.6.4.6	0.446
3jt4	H4B	Nitric oxide synthase, brain	1.14.13.39	0.446
3jun	AKD	Phenazine biosynthesis protein A/B	/	0.446
3ufp	H4B	Nitric oxide synthase, brain	1.14.13.39	0.446
3uft	H4B	Nitric oxide synthase, brain	1.14.13.39	0.446
1xmm	M7G	m7GpppX diphosphatase	3.6.1.59	0.445
2bo7	GDP	Mannosylglycerate synthase	/	0.445
2e77	FMN	Lactate oxidase	/	0.445
2toh	HBI	Tyrosine 3-monooxygenase	1.14.16.2	0.445
3inr	GDU	UDP-galactopyranose mutase	5.4.99.9	0.445
3kxo	KXO	Hematopoietic prostaglandin D synthase	/	0.445
3l7l	C2G	Teichoic acid poly(glycerol phosphate) polymerase	/	0.445
1n71	COA	Aac(6')-Ii protein	/	0.444
1uze	EAL	Angiotensin-converting enzyme	3.2.1	0.444
2ydd	2AM	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.444
3gya	COA	GCN5-related N-acetyltransferase	/	0.444
3p84	FMN	Pentaerythritol tetranitrate reductase	/	0.444
4fvy	H4B	Nitric oxide synthase, brain	1.14.13.39	0.444
5bsr	COA	4-coumarate--CoA ligase 2	6.2.1.12	0.444
1kvs	UPG	UDP-glucose 4-epimerase	5.1.3.2	0.443
1p6j	H4B	Nitric oxide synthase, brain	1.14.13.39	0.443
1uae	UD1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	/	0.443
2vd0	D27	Hematopoietic prostaglandin D synthase	/	0.443
3ckq	UPG	Glucosyl-3-phosphoglycerate synthase	2.4.1.266	0.443
3ed1	GA3	Gibberellin receptor GID1	/	0.443
4cx4	H4B	Nitric oxide synthase, brain	1.14.13.39	0.443
1hlk	113	Metallo-beta-lactamase type 2	/	0.442
1mb9	ATP	Carboxyethyl-arginine beta-lactam-synthase	6.3.3.4	0.442
1u1g	BBB	Uridine phosphorylase	2.4.2.3	0.442
2j9g	ADP	Biotin carboxylase	6.3.4.14	0.442
2ov2	GCP	Ras-related C3 botulinum toxin substrate 3	/	0.442
3px3	T3Q	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase	2.1.1.235	0.442
4cf7	ADP	Adenylate kinase	/	0.442
1rs7	H4B	Nitric oxide synthase, brain	1.14.13.39	0.441
2g6i	HBI	Nitric oxide synthase, brain	1.14.13.39	0.441
3kr6	UD1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	/	0.441
3x2w	ATP	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.441
4itx	IN5	Cystathionine beta-lyase MetC	4.4.1.8	0.441
4ivq	I43	Thymidine kinase	/	0.441
4lzw	THM	Uridine phosphorylase	/	0.441
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.440
1t91	GTP	Ras-related protein Rab-7a	/	0.440
2x1e	X1E	Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form	2.3.1.164	0.440
4nu0	AP5	Adenylate kinase	/	0.440