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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zda32UProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zda32UProthrombin3.4.21.51.000
2zfr46UProthrombin3.4.21.50.833
2zhf49UProthrombin3.4.21.50.818
2zdv37UProthrombin3.4.21.50.792
2zg050UProthrombin3.4.21.50.792
2zgx29UProthrombin3.4.21.50.775
4ax9N5NProthrombin3.4.21.50.766
2zff53UProthrombin3.4.21.50.765
2zc922UProthrombin3.4.21.50.762
2zi224UProthrombin3.4.21.50.745
2zfq45UProthrombin3.4.21.50.733
3biu10UProthrombin3.4.21.50.733
2znk31UProthrombin3.4.21.50.726
2zhe13UProthrombin3.4.21.50.702
2v3oI26Prothrombin3.4.21.50.699
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.695
2ziq26UProthrombin3.4.21.50.691
1d4pBPPProthrombin3.4.21.50.690
2zfp19UProthrombin3.4.21.50.688
2zgb21UProthrombin3.4.21.50.688
2zhq27UProthrombin3.4.21.50.684
1d3dBZTProthrombin3.4.21.50.683
2anmCDOProthrombin3.4.21.50.683
2r2mI50Prothrombin3.4.21.50.683
3eq02TSProthrombin3.4.21.50.680
3dux64UProthrombin3.4.21.50.672
3qto10PProthrombin3.4.21.50.671
3biv11UProthrombin3.4.21.50.670
1ypeUIPProthrombin3.4.21.50.669
1ypgUIRProthrombin3.4.21.50.669
1c4uIH1Prothrombin3.4.21.50.665
3p1799PProthrombin3.4.21.50.663
1xm1GAHProthrombin3.4.21.50.650
1d6w00RProthrombin3.4.21.50.649
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.649
4bamMM9Prothrombin3.4.21.50.648
2jh5895Prothrombin3.4.21.50.646
4bakM67Prothrombin3.4.21.50.642
3dhk23UProthrombin3.4.21.50.640
2zhw12UProthrombin3.4.21.50.639
3qwc98PProthrombin3.4.21.50.638
1nm6L86Prothrombin3.4.21.50.636
1ae8AZLProthrombin3.4.21.50.634
1t4v14AProthrombin3.4.21.50.634
1mu6CDAProthrombin3.4.21.50.633
2bdyUNBProthrombin3.4.21.50.630
2bvs2CEProthrombin3.4.21.50.630
1ypjUIBProthrombin3.4.21.50.629
2zf051UProthrombin3.4.21.50.628
4lxb7R9Prothrombin3.4.21.50.627
1yplRA8Prothrombin3.4.21.50.626
1k21IGNProthrombin3.4.21.50.625
4baoMVFProthrombin3.4.21.50.625
1z71L17Prothrombin3.4.21.50.622
2pksG44Prothrombin3.4.21.50.622
1sb1165Prothrombin3.4.21.50.621
2uuk897Prothrombin3.4.21.50.621
1d3pBT3Prothrombin3.4.21.50.620
1jwtBLIProthrombin3.4.21.50.619
1mueCDDProthrombin3.4.21.50.619
1ypkCCRProthrombin3.4.21.50.619
1ypmRA4Prothrombin3.4.21.50.618
1t4u81AProthrombin3.4.21.50.617
2jh6894Prothrombin3.4.21.50.617
4ayy9MXProthrombin3.4.21.50.617
2jh0701Prothrombin3.4.21.50.610
1afeALZProthrombin3.4.21.50.608
4bahMELProthrombin3.4.21.50.608
1ta6177Prothrombin3.4.21.50.604
3c1kT15Prothrombin3.4.21.50.603
1zrb062Prothrombin3.4.21.50.601
3c27DKKProthrombin3.4.21.50.597
1d9i00PProthrombin3.4.21.50.596
1zgv501Prothrombin3.4.21.50.592
4n3l2FNProthrombin3.4.21.50.591
1oytFSNProthrombin3.4.21.50.589
1c4yIH3Prothrombin3.4.21.50.582
4rn615UProthrombin3.4.21.50.581
1k22MELProthrombin3.4.21.50.579
4banM6SProthrombin3.4.21.50.575
2cf9348Prothrombin3.4.21.50.573
4baqM4ZProthrombin3.4.21.50.573
3qtv06PProthrombin3.4.21.50.571
1nzq162Prothrombin3.4.21.50.570
2cn0F25Prothrombin3.4.21.50.570
3utu1TSProthrombin3.4.21.50.570
1vzqSHYProthrombin3.4.21.50.567
2uuj896Prothrombin3.4.21.50.564
2gdeSN3Prothrombin3.4.21.50.562
2v3hI25Prothrombin3.4.21.50.560
4az29MUProthrombin3.4.21.50.560
4e7r0NWProthrombin3.4.21.50.554
1c4vIH2Prothrombin3.4.21.50.546
2cf8ESHProthrombin3.4.21.50.546
1mu8CDBProthrombin3.4.21.50.539
3egkM18Prothrombin3.4.21.50.537
1o0d163Prothrombin3.4.21.50.534
1zgi382Prothrombin3.4.21.50.531
4ayv9MQProthrombin3.4.21.50.531
4hfp15UProthrombin3.4.21.50.531
1a4wQWEProthrombin3.4.21.50.528
1w7gMIUProthrombin3.4.21.50.528
5cmx0G6Prothrombin3.4.21.50.525
1riwOSCProthrombin3.4.21.50.516
1uvsI11Prothrombin3.4.21.50.511
2bxtC2DProthrombin3.4.21.50.503
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.503
1ghv120Prothrombin3.4.21.50.502
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.492
1c5nESIProthrombin3.4.21.50.486
1bcuPRLProthrombin3.4.21.50.482
1o2g696Prothrombin3.4.21.50.481
1ktsC24Prothrombin3.4.21.50.480
1ta2176Prothrombin3.4.21.50.479
4kbyC2EStimulator of interferon genes protein/0.477
1gj4132Prothrombin3.4.21.50.474
4loy6XSProthrombin3.4.21.50.473
3f6891UProthrombin3.4.21.50.469
2a2xNA9Prothrombin3.4.21.50.468
3adaNADSubunit alpha of sarocosine oxidase/0.464
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.457
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3vqsJT1Genome polyprotein/0.454
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.453
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.451
4q71FADBifunctional protein PutA/0.449
4gxs0YSGlutamate receptor 2/0.447
1fmlRTLRetinol dehydratase/0.444
4a802ANMajor pollen allergen Bet v 1-A/0.444
1x8lOXRRetinol dehydratase/0.443
2nr4FMNConserved protein/0.441
4bttVYRCoagulation factor X3.4.21.60.441
1pqc444Oxysterols receptor LXR-beta/0.440
5dozNDPJamJ/0.440