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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2yquFADDihydrolipoyl dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2yquFADDihydrolipoyl dehydrogenase/1.000
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.628
3urhFADDihydrolipoyl dehydrogenase/0.610
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.587
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.587
4jq9FADDihydrolipoyl dehydrogenase/0.570
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.569
2eq9FADDihydrolipoyl dehydrogenase/0.569
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.567
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.548
3ladFADDihydrolipoyl dehydrogenase/0.547
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.543
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.540
1zk7FADMercuric reductase1.16.1.10.532
1zx9FADMercuric reductase1.16.1.10.530
2eq8FADDihydrolipoyl dehydrogenase/0.528
2r9zFADGlutathione amide reductase/0.499
3cgcFADCoenzyme A disulfide reductase/0.493
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.486
3cgbFADCoenzyme A disulfide reductase/0.485
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.481
4nevFADTrypanothione reductase/0.479
2eq7FADDihydrolipoyl dehydrogenase/0.478
2eq6FADDihydrolipoyl dehydrogenase/0.477
3icrFADCoenzyme A disulfide reductase/0.477
1gerFADGlutathione reductase1.8.1.70.475
4ocgFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.472
1nhpFADNADH peroxidase1.11.1.10.467
1febFADTrypanothione reductase1.8.1.120.465
3ic9FADPutative dihydrolipoamide dehydrogenase/0.465
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.465
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.464
1nhsFADNADH peroxidase1.11.1.10.461
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.461
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.460
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.457
3icsFADCoenzyme A disulfide reductase/0.457
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.457
1bzlFADTrypanothione reductase1.8.1.120.456
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.455
4j56FADThioredoxin reductase 21.8.1.90.454
1xdiFADNAD(P)H dehydrogenase (quinone)/0.452
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.451
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.450
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.449
1grhFADGlutathione reductase, mitochondrial1.8.1.70.446
1npxFADNADH peroxidase1.11.1.10.446
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.443
3ctyFADProbable thioredoxin reductase/0.443
3grsFADGlutathione reductase, mitochondrial1.8.1.70.443
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.443
1f8wFADNADH peroxidase1.11.1.10.442
1greFADGlutathione reductase, mitochondrial1.8.1.70.442
1feaFADTrypanothione reductase1.8.1.120.441
1onfFADGlutathione reductase1.8.1.70.441
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.441