sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2x7h | PFN | Prostaglandin reductase 3 | 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 1.000 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.506 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.481 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.479 | |
| 5dp2 | NAP | CurF | / | 0.479 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.462 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.458 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.455 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.453 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.453 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.451 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.450 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.447 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.446 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.446 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.446 | |
| 3lu8 | IQX | Serum albumin | / | 0.446 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.446 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.445 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.445 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.444 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.443 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.440 |