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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wzmNA7Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wzmNA7Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346/1.000
3ge6FMNNitroreductase/0.486
1orrCDPCDP-paratose 2-epimerase/0.480
1ah4NAPAldose reductase1.1.1.210.473
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.469
3wczNAPAldo-keto reductase AKR2E4/0.467
1pj2NAINAD-dependent malic enzyme, mitochondrial1.1.1.380.465
4auxXTCTetracycline repressor protein class D/0.465
1lqaNDPProtein tas/0.463
2hdjNDPAldo-keto reductase family 1 member C2/0.461
2oapANPType II secretion system protein (GspE-2)/0.461
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.461
4jq3NAPAldo-keto reductase family 1 member C2/0.461
2hejNDPAldo-keto reductase family 1 member C211.1.10.460
3akdCDPCytidylate kinase/0.460
4jtqNAPAldo-keto reductase family 1 member C2/0.460
4dieC5PCytidylate kinase/0.459
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.458
2gn4UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.458
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.458
1evjNADGlucose--fructose oxidoreductase1.1.99.280.456
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.456
2dteNAIGlucose 1-dehydrogenase related protein/0.455
2vojNADAlanine dehydrogenase1.4.1.10.455
5fkmTDCTetracycline repressor protein class D/0.455
5jlaNADPutative short-chain dehydrogenase/reductase/0.455
5kgpACOPredicted acetyltransferase/0.455
4l1xNAPAldo-keto reductase family 1 member C2/0.454
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.452
2he5NDPAldo-keto reductase family 1 member C211.1.10.452
2vhzNAIAlanine dehydrogenase1.4.1.10.452
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.451
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.451
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.451
1ae1NAPTropinone reductase 1/0.450
3d3wNAPL-xylulose reductase1.1.1.100.450
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4j36FADKynurenine 3-monooxygenase/0.450
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.449
4xo7NAPAldo-keto reductase family 1 member C2/0.448
2fzwNADAlcohol dehydrogenase class-31.1.1.10.447
2j8tNAPAldose reductase1.1.1.210.447
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.447
2bkjFMNNADPH-flavin oxidoreductase/0.446
1n5dNDPCarbonyl reductase [NADPH] 1/0.444
1az2NAPAldose reductase1.1.1.210.443
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.443
3juqAJDPhenazine biosynthesis protein A/B/0.443
4jtaNAPVoltage-gated potassium channel subunit beta-2/0.443
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.443
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.442
2acqNAPAldose reductase1.1.1.210.442
2j09FADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
3akeC5PCytidylate kinase/0.442
4b3aTACTetracycline repressor protein class D/0.442
5cfpC2EStimulator of interferon genes protein/0.442
5l3rGCPCell division protein FtsY homolog, chloroplastic/0.442
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
1x98NAPAldose reductase1.1.1.210.441
2eixFADNADH-cytochrome b5 reductase/0.441
2pa3NAID-3-phosphoglycerate dehydrogenase1.1.1.950.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.441
1pz1NAPGeneral stress protein 69/0.440
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.440
2p9eNAID-3-phosphoglycerate dehydrogenase1.1.1.950.440
3bmoNAPPteridine reductase/0.440
4fidGDPG protein alpha subunit, putative/0.440
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.440