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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vdgNDPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vdgNDPAldose reductase1.1.1.211.000
1x96NAPAldose reductase1.1.1.210.542
4xzmNAPAldo-keto reductase family 1 member B101.1.10.534
2j8tNAPAldose reductase1.1.1.210.533
4pmjNAPPutative oxidoreductase/0.532
3v36NAPAldose reductase1.1.1.210.530
3h7rNAPAldo-keto reductase family 4 member C8/0.527
1ah4NAPAldose reductase1.1.1.210.526
3q65NAPAldose reductase1.1.1.210.522
4xznNAPAldo-keto reductase family 1 member B101.1.10.511
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.509
1x98NAPAldose reductase1.1.1.210.507
2acqNAPAldose reductase1.1.1.210.505
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.505
4g5dNDPProstaglandin F synthase1.1.1.1880.505
2hdjNDPAldo-keto reductase family 1 member C2/0.503
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.502
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.502
3q67NAPAldose reductase1.1.1.210.499
4xo7NAPAldo-keto reductase family 1 member C2/0.498
5c7hNDPPutative oxidoreductase/0.498
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.497
2pfhNDPAldose reductase1.1.1.210.493
2pevNDPAldose reductase1.1.1.210.492
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.492
1z8aNAPAldose reductase1.1.1.210.490
2hejNDPAldo-keto reductase family 1 member C211.1.10.489
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.489
2iq0NAPAldose reductase1.1.1.210.485
1ef3NAPAldose reductase1.1.1.210.483
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.483
4jtqNAPAldo-keto reductase family 1 member C2/0.483
1adsNAPAldose reductase1.1.1.210.482
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.479
4jq3NAPAldo-keto reductase family 1 member C2/0.475
1az2NAPAldose reductase1.1.1.210.472
2pf8NDPAldose reductase1.1.1.210.472
4l1xNAPAldo-keto reductase family 1 member C2/0.470
1vp5NAPOxidoreductase, aldo/keto reductase family/0.465
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.461
3o3rNAPAldose reductase-related protein 11.1.1.210.459
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.451
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.451
2acsNAPAldose reductase1.1.1.210.450
1s1rNAPAldo-keto reductase family 1 member C3/0.448
2bgsNDPAldose reductase1.1.1.210.447
3qkzNAPAldose reductase-related protein 11.1.1.210.447
4ku5DCC3-oxoacyl-[ACP] synthase III/0.444
1s1pNAPAldo-keto reductase family 1 member C3/0.441