scPDB - Distribution of Binding site Similarity values of 2toh entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2toh	HBI	Tyrosine 3-monooxygenase	1.14.16.2

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2toh	HBI	Tyrosine 3-monooxygenase	1.14.16.2	1.000
1dmw	HBI	Phenylalanine-4-hydroxylase	1.14.16.1	0.566
1lrm	HBI	Phenylalanine-4-hydroxylase	1.14.16.1	0.557
4pah	LNR	Phenylalanine-4-hydroxylase	1.14.16.1	0.557
3pah	XDE	Phenylalanine-4-hydroxylase	1.14.16.1	0.547
5pah	LDP	Phenylalanine-4-hydroxylase	1.14.16.1	0.545
1tg2	H2B	Phenylalanine-4-hydroxylase	1.14.16.1	0.543
1j8u	H4B	Phenylalanine-4-hydroxylase	1.14.16.1	0.511
2vn1	FK5	Peptidylprolyl isomerase	/	0.485
1ltz	HBI	Phenylalanine-4-hydroxylase	1.14.16.1	0.476
4cdm	FO1	Deoxyribodipyrimidine photolyase	/	0.473
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.469
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.468
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.465
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.463
1sre	HAB	Streptavidin	/	0.463
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.462
3nmp	PYV	Abscisic acid receptor PYL2	/	0.462
3up3	XCA	aceDAF-12	/	0.462
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.461
3pz2	3PZ	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.461
1zdw	FLV	Prenyltransferase	/	0.460
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.460
3aos	JH2	Hemolymph juvenile hormone binding protein	/	0.460
4ge4	0KE	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.460
4h6p	FMN	Chromate reductase	/	0.460
3c3d	FO1	2-phospho-L-lactate transferase	/	0.459
1mmk	H4B	Phenylalanine-4-hydroxylase	1.14.16.1	0.458
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.458
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.457
1axw	MTX	Thymidylate synthase	/	0.455
1jnr	FAD	Adenylylsulfate reductase, subunit A (AprA)	/	0.455
1z6t	ADP	Apoptotic protease-activating factor 1	/	0.455
2p9g	NAI	D-3-phosphoglycerate dehydrogenase	1.1.1.95	0.455
3k3h	BYE	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.454
3n19	FNR	Xenobiotic reductase	/	0.454
1swt	BTN	Streptavidin	/	0.452
4ge7	0K5	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.452
4lm4	JPZ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.452
3sn6	P0G	Beta-2 adrenergic receptor	/	0.452
1fml	RTL	Retinol dehydratase	/	0.450
1kw0	H4B	Phenylalanine-4-hydroxylase	1.14.16.1	0.450
2xve	FAD	Putative flavin-containing monooxygenase	/	0.450
4twn	B96	Ephrin type-A receptor 3	2.7.10.1	0.450
1ot7	IU5	Bile acid receptor	/	0.449
3bxx	QUE	Dihydroflavonol 4-reductase	1.1.1.219	0.449
5dp2	NAP	CurF	/	0.449
1nce	CB3	Thymidylate synthase	/	0.448
1tdu	DUR	Thymidylate synthase	/	0.448
2w4q	CBW	Prostaglandin reductase 2	1.3.1.48	0.448
4dpy	2P0	Mevalonate diphosphate decarboxylase	/	0.448
4dre	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.448
4l8u	9AZ	Serum albumin	/	0.448
1dgf	NDP	Catalase	1.11.1.6	0.447
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.447
3qm4	PN0	Cytochrome P450 2D6	/	0.447
4cvm	ANP	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	/	0.447
4glx	0XS	DNA ligase	6.5.1.2	0.447
4rtl	SFG	DNA adenine methylase	2.1.1.72	0.447
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.446
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.446
3fzn	D7K	Benzoylformate decarboxylase	4.1.1.7	0.446
3w6h	AZM	Carbonic anhydrase 1	4.2.1.1	0.446
4ts7	ADP	Purine phosphoribosyltransferase (GpT-1)	/	0.446
1df8	BTN	Streptavidin	/	0.445
4fam	0SZ	Aldo-keto reductase family 1 member C3	/	0.445
4uug	PXG	Branched-chain amino acid aminotransferase, putative	/	0.445
1ao8	MTX	Dihydrofolate reductase	1.5.1.3	0.444
1xdd	AAY	Integrin alpha-L	/	0.444
3fu9	KIB	Laccase-1	1.10.3.2	0.444
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.444
3zht	TD9	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.444
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.443
2bu9	HFV	Isopenicillin N synthase	1.21.3.1	0.443
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.443
1jtu	LYB	Thymidylate synthase	/	0.442
1lkd	BP6	Biphenyl-2,3-diol 1,2-dioxygenase	1.13.11.39	0.442
4ajm	3A6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.442
1zx1	CB1	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.441
2fhn	BNI	Avidin-related protein 4/5	/	0.441
4dqu	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.441
4epl	JAI	Jasmonic acid-amido synthetase JAR1	6.3.2	0.441
4kp6	1S1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.441
1qvu	PRL	HTH-type transcriptional regulator QacR	/	0.440
2cje	DUN	DUTPase	/	0.440
2lba	CHO	Fatty acid binding protein 6	/	0.440
3ey4	352	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.440
3fhx	PLP	Pyridoxal kinase	2.7.1.35	0.440
3mnr	SD1	Heat shock protein HSP 90-alpha	/	0.440
3sf6	FDA	Glutaryl-CoA dehydrogenase	/	0.440
4hbm	0Y7	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.440
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.440