scPDB - Distribution of Binding site Similarity values of 2r5n entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2r5n	TPP	Transketolase 1

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2r5n	TPP	Transketolase 1	/	1.000
1itz	TPP	Transketolase, chloroplastic	2.2.1.1	0.655
1trk	TPP	Transketolase 1	2.2.1.1	0.653
3upt	TPP	Transketolase	/	0.653
1tka	N3T	Transketolase 1	2.2.1.1	0.631
1ngs	TPP	Transketolase 1	2.2.1.1	0.628
1tkb	N1T	Transketolase 1	2.2.1.1	0.622
2g25	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.605
1ay0	TPP	Transketolase 1	2.2.1.1	0.593
1tkc	M6T	Transketolase 1	2.2.1.1	0.570
3rim	TPP	Transketolase	2.2.1.1	0.556
1umc	TDP	2-oxoisovalerate dehydrogenase subunit alpha	1.2.4.4	0.522
1umc	TDP	2-oxoisovalerate dehydrogenase subunit beta	1.2.4.4	0.522
3lq4	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.513
2o1s	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.507
2j9f	THV	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	1.2.4.4	0.497
2j9f	THV	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	1.2.4.4	0.497
2o1x	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.496
1rp7	TZD	Pyruvate dehydrogenase E1 component	1.2.4.1	0.494
3zhu	TD8	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.493
1kqw	RTL	Cellular retinol-binding protein type II	/	0.487
2v58	LZJ	Biotin carboxylase	6.3.4.14	0.485
1fml	RTL	Retinol dehydratase	/	0.474
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.470
2iea	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.467
1nup	NMN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.466
3zhs	TD6	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.463
4dpy	2P0	Mevalonate diphosphate decarboxylase	/	0.461
3h3s	H15	Collagen type IV alpha-3-binding protein	/	0.460
2v5a	LZL	Biotin carboxylase	6.3.4.14	0.458
4m83	ERY	Oleandomycin glycosyltransferase	2.4.1	0.458
4qzu	RTL	Retinol-binding protein 2	/	0.457
2v59	LZK	Biotin carboxylase	6.3.4.14	0.456
4an4	DUD	Putative glycosyl transferase	/	0.456
5esd	TDP	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	/	0.454
3gfb	NAD	L-threonine 3-dehydrogenase	/	0.453
1l8a	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.452
2fj1	CTC	Tetracycline repressor protein class D	/	0.452
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
3wqm	B29	Diterpene synthase	3.1.7.8	0.450
1k27	MTM	S-methyl-5'-thioadenosine phosphorylase	/	0.446
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.446
4dja	FAD	(6-4) photolyase	/	0.446
4eb7	PLP	Cysteine desulfurase IscS 2	/	0.446
5fd8	A5A	Putative carboxypeptidase yocD	/	0.446
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.445
3af1	GDP	Pantothenate kinase	2.7.1.33	0.445
4hp8	NAP	2-deoxy-D-gluconate 3-dehydrogenase	/	0.445
1xl8	152	Peroxisomal carnitine O-octanoyltransferase	2.3.1.137	0.444
4k9o	TPP	Benzoylformate decarboxylase	4.1.1.7	0.444
3sn6	P0G	Beta-2 adrenergic receptor	/	0.444
2v3w	TPP	Benzoylformate decarboxylase	4.1.1.7	0.442
4fm8	0UQ	Beta-secretase 1	3.4.23.46	0.442
4k9n	TZD	Benzoylformate decarboxylase	4.1.1.7	0.442
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.441
2ejv	NAD	L-threonine 3-dehydrogenase	/	0.441
2g28	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.440
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.440
4h6p	FMN	Chromate reductase	/	0.440