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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2qaeFADDihydrolipoyl dehydrogenase1.8.1.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2qaeFADDihydrolipoyl dehydrogenase1.8.1.41.000
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.635
3urhFADDihydrolipoyl dehydrogenase/0.613
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.608
2yquFADDihydrolipoyl dehydrogenase/0.607
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.596
3ladFADDihydrolipoyl dehydrogenase/0.590
2eq9FADDihydrolipoyl dehydrogenase/0.583
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.580
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.569
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.556
1zx9FADMercuric reductase1.16.1.10.549
4jq9FADDihydrolipoyl dehydrogenase/0.549
2r9zFADGlutathione amide reductase/0.538
1zk7FADMercuric reductase1.16.1.10.535
2eq8FADDihydrolipoyl dehydrogenase/0.532
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.515
3ic9FADPutative dihydrolipoamide dehydrogenase/0.511
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.508
3cgcFADCoenzyme A disulfide reductase/0.487
2eq7FADDihydrolipoyl dehydrogenase/0.481
2eq6FADDihydrolipoyl dehydrogenase/0.478
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.477
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.477
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.476
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.474
4j56FADThioredoxin reductase 21.8.1.90.473
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.471
3cgbFADCoenzyme A disulfide reductase/0.471
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.467
4ocgFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.467
1gerFADGlutathione reductase1.8.1.70.466
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.466
1nhpFADNADH peroxidase1.11.1.10.464
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.464
3icrFADCoenzyme A disulfide reductase/0.461
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.459
1nhsFADNADH peroxidase1.11.1.10.459
4nevFADTrypanothione reductase/0.455
1xdiFADNAD(P)H dehydrogenase (quinone)/0.454
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.454
1k0lFADp-hydroxybenzoate hydroxylase/0.453
1npxFADNADH peroxidase1.11.1.10.452
1febFADTrypanothione reductase1.8.1.120.451
1grhFADGlutathione reductase, mitochondrial1.8.1.70.450
3grsFADGlutathione reductase, mitochondrial1.8.1.70.450
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.450
1onfFADGlutathione reductase1.8.1.70.449
3icsFADCoenzyme A disulfide reductase/0.448
1f8wFADNADH peroxidase1.11.1.10.447
1bzlFADTrypanothione reductase1.8.1.120.444
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.444
1grgFADGlutathione reductase, mitochondrial1.8.1.70.443
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.443
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.443
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.441
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441