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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pupADPMethylthioribose kinase2.7.1.100

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pupADPMethylthioribose kinase2.7.1.1001.000
2puiADPMethylthioribose kinase2.7.1.1000.665
2pulACPMethylthioribose kinase2.7.1.1000.613
2punACPMethylthioribose kinase2.7.1.1000.579
2olcADPMethylthioribose kinase2.7.1.1000.573
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.498
3eej53RUncharacterized protein/0.492
3eem53VUncharacterized protein/0.474
3u8hBHPPhospholipase A2, membrane associated/0.474
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.471
3pwhZMAAdenosine receptor A2a/0.470
3ix9MTXDihydrofolate reductase1.5.1.30.469
3qlxQLRUncharacterized protein/0.467
1x8b824Wee1-like protein kinase2.7.10.20.462
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.462
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.462
2bkkADPAminoglycoside 3'-phosphotransferase2.7.1.950.461
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
3qly55VUncharacterized protein/0.461
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.461
3wowANPCasein kinase II subunit alpha2.7.11.10.459
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.459
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.456
4ele31IDihydrofolate reductase/0.456
4k33ACPFibroblast growth factor receptor 32.7.10.10.456
5kgpACOPredicted acetyltransferase/0.456
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.455
3rucUD2UDP-N-acetylglucosamine 4-epimerase/0.454
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.454
2qllPLPGlycogen phosphorylase, liver form2.4.1.10.453
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.452
2plmSIB5-methylthioadenosine/S-adenosylhomocysteine deaminase3.5.4.280.452
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.452
3reyXACAdenosine receptor A2a/0.452
2wleCOAPolysialic acid O-acetyltransferase/0.451
3igoANPCalmodulin-domain protein kinase 1, putative/0.450
3ortAGSSerine/threonine protein kinase/0.450
1yqj6NPMitogen-activated protein kinase 14/0.449
2pywADPMethylthioribose kinase2.7.1.1000.449
4jrnANPRhoptry kinase family protein/0.449
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.448
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3eek53SUncharacterized protein/0.446
4crsAGSSerine/threonine-protein kinase N22.7.11.130.446
1ir3ANPInsulin receptor2.7.10.10.445
1kqwRTLCellular retinol-binding protein type II/0.445
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.445
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.445
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4r20AERCytochrome P450 family 17 polypeptide 2/0.444
4ztvTA7Anthranilate phosphoribosyltransferase/0.444
3itzP66Mitogen-activated protein kinase 14/0.443
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.442
4bbe3O4Tyrosine-protein kinase JAK2/0.442
2cdcNAPGlucose 1-dehydrogenase/0.441
2imkGTXAGAP009194-PA/0.441
2vbdV10Isopenicillin N synthase1.21.3.10.441
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.441
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.440
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.440
3d5wADPSerine/threonine-protein kinase PLK/0.440
3ihgVAKAklavinone 12-hydroxylase RdmE/0.440
4bfsZVSPantothenate kinase2.7.1.330.440
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440