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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pfhNDPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pfhNDPAldose reductase1.1.1.211.000
2iq0NAPAldose reductase1.1.1.210.666
2acqNAPAldose reductase1.1.1.210.657
2pf8NDPAldose reductase1.1.1.210.650
1z8aNAPAldose reductase1.1.1.210.641
1x96NAPAldose reductase1.1.1.210.636
1az2NAPAldose reductase1.1.1.210.635
3q65NAPAldose reductase1.1.1.210.631
3q67NAPAldose reductase1.1.1.210.631
2pevNDPAldose reductase1.1.1.210.630
2j8tNAPAldose reductase1.1.1.210.629
3v36NAPAldose reductase1.1.1.210.629
1x98NAPAldose reductase1.1.1.210.627
1ah4NAPAldose reductase1.1.1.210.605
1adsNAPAldose reductase1.1.1.210.602
2acsNAPAldose reductase1.1.1.210.589
3h7rNAPAldo-keto reductase family 4 member C8/0.575
2acuNAPAldose reductase1.1.1.210.564
3o3rNAPAldose reductase-related protein 11.1.1.210.556
4g5dNDPProstaglandin F synthase1.1.1.1880.548
4pmjNAPPutative oxidoreductase/0.545
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.544
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.535
3qkzNAPAldose reductase-related protein 11.1.1.210.535
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.531
2hejNDPAldo-keto reductase family 1 member C211.1.10.525
1zgdNAPChalcone reductase/0.518
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.516
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.515
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.514
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.514
4jtqNAPAldo-keto reductase family 1 member C2/0.513
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.504
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.503
1s1rNAPAldo-keto reductase family 1 member C3/0.501
5c7hNDPPutative oxidoreductase/0.499
3wczNAPAldo-keto reductase AKR2E4/0.496
4jq3NAPAldo-keto reductase family 1 member C2/0.493
4dz5NAPAldo-keto reductase family 1 member C3/0.490
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.488
1ef3NAPAldose reductase1.1.1.210.485
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.483
2hdjNDPAldo-keto reductase family 1 member C2/0.483
4xo7NAPAldo-keto reductase family 1 member C2/0.482
1c9wNAPAldose reductase-related protein 2/0.477
1vp5NAPOxidoreductase, aldo/keto reductase family/0.477
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.477
4l1xNAPAldo-keto reductase family 1 member C2/0.476
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.474
2p5nNDPAldo-keto reductase family 1 member C211.1.10.473
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.473
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.470
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.468
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.467
1lqaNDPProtein tas/0.462
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.460
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.458
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.455
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.445
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.442
2vdgNDPAldose reductase1.1.1.210.441