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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdxZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdxZSTAldose reductase1.1.1.211.000
2fz9ZSTAldose reductase1.1.1.210.722
2hv5ZSTAldose reductase1.1.1.210.686
2dv0ZSTAldose reductase1.1.1.210.677
3m4h388Aldose reductase1.1.1.210.648
2hvnZSTAldose reductase1.1.1.210.637
3lboLDTAldose reductase1.1.1.210.614
3lqlLDTAldose reductase1.1.1.210.611
4gca2X9Aldose reductase1.1.1.210.606
3ghuLDTAldose reductase1.1.1.210.591
2pdmZSTAldose reductase1.1.1.210.585
3mb9ZSTAldose reductase1.1.1.210.582
2pdu393Aldose reductase1.1.1.210.581
2pdp393Aldose reductase1.1.1.210.580
3lz5LDTAldose reductase1.1.1.210.580
3m64393Aldose reductase1.1.1.210.580
2fz8ZSTAldose reductase1.1.1.210.579
2hvoZSTAldose reductase1.1.1.210.578
1t40ID5Aldose reductase1.1.1.210.570
1z3n3NAAldose reductase1.1.1.210.570
1t41ID5Aldose reductase1.1.1.210.567
2fzdTOLAldose reductase1.1.1.210.558
1us0LDTAldose reductase1.1.1.210.550
2ikj393Aldose reductase1.1.1.210.549
3m0iZSTAldose reductase1.1.1.210.549
1z8962PAldose reductase1.1.1.210.548
1ieiZESAldose reductase1.1.1.210.547
2duxZSTAldose reductase1.1.1.210.543
3ghsLDTAldose reductase1.1.1.210.543
2i16LDTAldose reductase1.1.1.210.541
2pdg47DAldose reductase1.1.1.210.534
2pdh47DAldose reductase1.1.1.210.534
2pzn393Aldose reductase1.1.1.210.532
4yu153NAldose reductase1.1.1.210.532
2pdbZSTAldose reductase1.1.1.210.531
3ghrLDTAldose reductase1.1.1.210.530
2iki388Aldose reductase1.1.1.210.528
2pdfZSTAldose reductase1.1.1.210.528
3lenZSTAldose reductase1.1.1.210.526
2pd5ZSTAldose reductase1.1.1.210.525
3t423T4Aldose reductase1.1.1.210.525
2qxwLDTAldose reductase1.1.1.210.523
2i17LDTAldose reductase1.1.1.210.519
3ghtLDTAldose reductase1.1.1.210.518
1pwlBFIAldose reductase1.1.1.210.517
2pdc393Aldose reductase1.1.1.210.517
3ld5LDTAldose reductase1.1.1.210.516
3g5eQ74Aldose reductase1.1.1.210.515
2ikhLITAldose reductase1.1.1.210.508
1frbZSTAldose reductase-related protein 2/0.506
2pdj393Aldose reductase1.1.1.210.506
3mc5393Aldose reductase1.1.1.210.502
2pdn47DAldose reductase1.1.1.210.499
2pdiZSTAldose reductase1.1.1.210.475
2pdlTOLAldose reductase1.1.1.210.473
1zuaTOLAldo-keto reductase family 1 member B101.1.10.467
1ry8RUTAldo-keto reductase family 1 member C3/0.465
2f2kTGGAldose reductase1.1.1.210.465
2duzZSTAldose reductase1.1.1.210.462
1el3I84Aldose reductase1.1.1.210.460
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4ga8SBIAldo-keto reductase family 1 member B101.1.10.454
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2pdq47DAldose reductase1.1.1.210.452
2y1x845Histone-arginine methyltransferase CARM1/0.452
4j7hTRHPCZA361.3/0.451
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.447
2f3815MAldo-keto reductase family 1 member C3/0.446
1drfFOLDihydrofolate reductase1.5.1.30.445
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
5d5aCAUBeta-2 adrenergic receptor/0.445
2aovC2MHistamine N-methyltransferase2.1.1.80.444
4bj9UHBTankyrase-22.4.2.300.444
1ah3TOLAldose reductase1.1.1.210.443
2xejOKDGlutamate carboxypeptidase 23.4.17.210.443
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.443
3zkyWT4Isopenicillin N synthase1.21.3.10.443
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.442
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.441
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.440
3u2cSUZAldose reductase1.1.1.210.440
4wevSUZAldo-keto reductase family 1 member B101.1.10.440