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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdh47DAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdh47DAldose reductase1.1.1.211.000
2pdfZSTAldose reductase1.1.1.210.647
2pdn47DAldose reductase1.1.1.210.567
2hvoZSTAldose reductase1.1.1.210.562
2fz8ZSTAldose reductase1.1.1.210.557
2dv0ZSTAldose reductase1.1.1.210.553
2pdg47DAldose reductase1.1.1.210.552
2pdlTOLAldose reductase1.1.1.210.551
4gca2X9Aldose reductase1.1.1.210.548
2pdiZSTAldose reductase1.1.1.210.547
2fzdTOLAldose reductase1.1.1.210.546
2hv5ZSTAldose reductase1.1.1.210.544
2hvnZSTAldose reductase1.1.1.210.543
2pdj393Aldose reductase1.1.1.210.543
2pdmZSTAldose reductase1.1.1.210.540
3m0iZSTAldose reductase1.1.1.210.540
3mb9ZSTAldose reductase1.1.1.210.538
1ah3TOLAldose reductase1.1.1.210.536
1zuaTOLAldo-keto reductase family 1 member B101.1.10.532
1t40ID5Aldose reductase1.1.1.210.529
2fz9ZSTAldose reductase1.1.1.210.527
2pdbZSTAldose reductase1.1.1.210.526
2pdu393Aldose reductase1.1.1.210.526
2ikj393Aldose reductase1.1.1.210.525
2pzn393Aldose reductase1.1.1.210.524
3t423T4Aldose reductase1.1.1.210.524
2iki388Aldose reductase1.1.1.210.521
2pdxZSTAldose reductase1.1.1.210.521
1z8962PAldose reductase1.1.1.210.519
3ghtLDTAldose reductase1.1.1.210.519
3m64393Aldose reductase1.1.1.210.517
2i16LDTAldose reductase1.1.1.210.516
1z3n3NAAldose reductase1.1.1.210.514
1t41ID5Aldose reductase1.1.1.210.513
2duxZSTAldose reductase1.1.1.210.513
3lboLDTAldose reductase1.1.1.210.513
3ghsLDTAldose reductase1.1.1.210.512
3ghuLDTAldose reductase1.1.1.210.510
3mc5393Aldose reductase1.1.1.210.510
3ghrLDTAldose reductase1.1.1.210.509
3m4h388Aldose reductase1.1.1.210.508
2i17LDTAldose reductase1.1.1.210.507
2fzbTOLAldose reductase1.1.1.210.506
1pwlBFIAldose reductase1.1.1.210.505
3ld5LDTAldose reductase1.1.1.210.505
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.503
3g5eQ74Aldose reductase1.1.1.210.502
2pd5ZSTAldose reductase1.1.1.210.501
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.500
3lqlLDTAldose reductase1.1.1.210.499
1us0LDTAldose reductase1.1.1.210.497
2qxwLDTAldose reductase1.1.1.210.495
2duzZSTAldose reductase1.1.1.210.494
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.494
3lenZSTAldose reductase1.1.1.210.492
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.490
3lz5LDTAldose reductase1.1.1.210.483
3v94WYQPhosphodiesterase/0.481
2pdp393Aldose reductase1.1.1.210.480
2inzOHPAldose reductase1.1.1.210.478
1ieiZESAldose reductase1.1.1.210.473
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.473
2pdq47DAldose reductase1.1.1.210.472
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.470
4yu153NAldose reductase1.1.1.210.470
1frbZSTAldose reductase-related protein 2/0.467
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
4dbs0HVAldo-keto reductase family 1 member C3/0.466
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2aot2PMHistamine N-methyltransferase2.1.1.80.460
2v0mKLNCytochrome P450 3A4/0.457
3s3gTLTAldose reductase1.1.1.210.457
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.457
1ry0PG2Aldo-keto reductase family 1 member C3/0.456
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2ikhLITAldose reductase1.1.1.210.455
1ry8RUTAldo-keto reductase family 1 member C3/0.454
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.453
1zq5E04Aldo-keto reductase family 1 member C3/0.453
2pdwFIDAldose reductase1.1.1.210.453
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.453
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2pdc393Aldose reductase1.1.1.210.452
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.452
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2f3815MAldo-keto reductase family 1 member C3/0.451
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3k1wBFXRenin3.4.23.150.449
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2pdyFIDAldose reductase1.1.1.210.448
4li61XOTankyrase-12.4.2.300.448
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3dlaNXXGlutamine-dependent NAD(+) synthetase6.3.5.10.446
3n0hTOPDihydrofolate reductase1.5.1.30.445
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2cekN8TAcetylcholinesterase3.1.1.70.444
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.444
3a1l2CCCytochrome P450/0.444
5bn4ANPV-type ATP synthase alpha chain/0.444
1obnASVIsopenicillin N synthase1.21.3.10.443
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4dbw511Aldo-keto reductase family 1 member C3/0.442
4j7gTRHPCZA361.3/0.442
4fam0SZAldo-keto reductase family 1 member C3/0.441
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.440
2is72CLAldose reductase1.1.1.210.440
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3hywDCQSulfide-quinone reductase/0.440