sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2o7p | NAP | Riboflavin biosynthesis protein RibD |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 1.000 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.478 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.477 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.474 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 1osv | CHC | Bile acid receptor | / | 0.471 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.469 | |
| 5dp2 | NAP | CurF | / | 0.469 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.467 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.467 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.467 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.466 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.465 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.465 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.464 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.462 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.461 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.460 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.458 | |
| 1ie4 | T44 | Transthyretin | / | 0.455 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.455 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.455 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.452 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.452 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.451 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.450 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.449 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.449 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 4l8u | 9AZ | Serum albumin | / | 0.448 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.447 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.447 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.447 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.447 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.446 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.446 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.446 | |
| 3zux | TCH | Transporter | / | 0.446 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.446 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.445 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.445 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4rek | FAD | Cholesterol oxidase | 1.1.3.6 | 0.445 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.444 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.444 | |
| 1e1m | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.443 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.443 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.442 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.442 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.442 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.441 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.441 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3gyi | FAD | Cholesterol oxidase | 1.1.3.6 | 0.440 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.440 |