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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2nvdITBAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2nvdITBAldose reductase1.1.1.211.000
1az1ALRAldose reductase1.1.1.210.548
4q0kGA3Phytohormone-binding protein/0.500
1r5gAO1Methionine aminopeptidase 2/0.485
2bf4FMNNADPH--cytochrome P450 reductase/0.481
1yw9A84Methionine aminopeptidase 2/0.477
4qa0SHHHistone deacetylase 83.5.1.980.475
3qe2FMNNADPH--cytochrome P450 reductase/0.473
1dx6GNTAcetylcholinesterase3.1.1.70.472
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.471
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.471
2ea4F79Methionine aminopeptidase 2/0.469
4psbGA3Cytokinin-specific binding protein/0.469
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.469
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.466
2gv8NDPThiol-specific monooxygenase1.14.130.462
3hl0NADMaleylacetate reductase/0.462
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.461
1eveE20Acetylcholinesterase3.1.1.70.459
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2ipw2CLAldose reductase1.1.1.210.459
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.459
2pdkSBIAldose reductase1.1.1.210.458
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.457
1w6rGNTAcetylcholinesterase3.1.1.70.457
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.457
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.457
3ug8IMNAldo-keto reductase family 1 member C3/0.454
1qtiGNTAcetylcholinesterase3.1.1.70.453
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2wzySQXSoluble acetylcholine receptor/0.453
3bw2FMNPutative 2-nitropropane dioxygenase/0.453
4c5oFADPutative monooxygenase/0.453
2whqHI6Acetylcholinesterase3.1.1.70.452
3bw4FMNPutative 2-nitropropane dioxygenase/0.452
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.451
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.451
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.451
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.451
1g63FMNEpidermin decarboxylase4.1.10.450
2a3bCFFEndochitinase B13.2.1.140.450
2ga2A19Methionine aminopeptidase 2/0.450
1gpnHUBAcetylcholinesterase3.1.1.70.449
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.449
2jf0HBPAcetylcholinesterase3.1.1.70.449
1pq944BOxysterols receptor LXR-beta/0.448
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.448
1jg0DDTThymidylate synthase/0.446
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.446
4bftZVTPantothenate kinase2.7.1.330.445
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.445
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.445
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.444
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4bfyZVYPantothenate kinase2.7.1.330.444
4hcy0YNTransketolase/0.444
4m0f1YKAcetylcholinesterase3.1.1.70.444
1dduDDUThymidylate synthase/0.443
2g1s4IGRenin3.4.23.150.443
3c3xNAPEugenol synthase 11.1.1.3180.443
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4lrrCF9Thymidylate synthase/0.443
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.443
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.442
4bfvZVVPantothenate kinase2.7.1.330.442
1dduCB3Thymidylate synthase/0.441
1odcA8BAcetylcholinesterase3.1.1.70.441
1q13TESProstaglandin-E(2) 9-reductase1.1.1.1890.441
2bn4FMNNADPH--cytochrome P450 reductase/0.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
2w6cBM4Acetylcholinesterase3.1.1.70.441
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.441
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.441
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.441
4dbw511Aldo-keto reductase family 1 member C3/0.441
4gddNAIUDP-galactopyranose mutase/0.441
1c7oPPGHemolysin/0.440
1h22E10Acetylcholinesterase3.1.1.70.440
4rxqDUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440