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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fz9ZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fz9ZSTAldose reductase1.1.1.211.000
2dv0ZSTAldose reductase1.1.1.210.809
2hv5ZSTAldose reductase1.1.1.210.765
2pdxZSTAldose reductase1.1.1.210.742
2hvnZSTAldose reductase1.1.1.210.714
3m4h388Aldose reductase1.1.1.210.676
2ikj393Aldose reductase1.1.1.210.675
2fz8ZSTAldose reductase1.1.1.210.669
3m64393Aldose reductase1.1.1.210.666
4gca2X9Aldose reductase1.1.1.210.658
3lqlLDTAldose reductase1.1.1.210.656
1z8962PAldose reductase1.1.1.210.650
3lboLDTAldose reductase1.1.1.210.649
2pdmZSTAldose reductase1.1.1.210.645
1t40ID5Aldose reductase1.1.1.210.631
3mb9ZSTAldose reductase1.1.1.210.631
2pdu393Aldose reductase1.1.1.210.619
2iki388Aldose reductase1.1.1.210.608
1t41ID5Aldose reductase1.1.1.210.607
1z3n3NAAldose reductase1.1.1.210.607
2pdp393Aldose reductase1.1.1.210.598
2fzdTOLAldose reductase1.1.1.210.580
2pdh47DAldose reductase1.1.1.210.579
2hvoZSTAldose reductase1.1.1.210.573
3lenZSTAldose reductase1.1.1.210.573
3t423T4Aldose reductase1.1.1.210.573
1ieiZESAldose reductase1.1.1.210.569
1pwlBFIAldose reductase1.1.1.210.569
2i16LDTAldose reductase1.1.1.210.568
3lz5LDTAldose reductase1.1.1.210.568
2ikhLITAldose reductase1.1.1.210.565
2pdfZSTAldose reductase1.1.1.210.562
2pzn393Aldose reductase1.1.1.210.561
2pdbZSTAldose reductase1.1.1.210.556
2pdg47DAldose reductase1.1.1.210.555
3g5eQ74Aldose reductase1.1.1.210.553
2qxwLDTAldose reductase1.1.1.210.548
3ghrLDTAldose reductase1.1.1.210.547
3m0iZSTAldose reductase1.1.1.210.545
2pd5ZSTAldose reductase1.1.1.210.544
2pdlTOLAldose reductase1.1.1.210.538
3mc5393Aldose reductase1.1.1.210.536
4yu153NAldose reductase1.1.1.210.531
2pdc393Aldose reductase1.1.1.210.529
1us0LDTAldose reductase1.1.1.210.528
2pdyFIDAldose reductase1.1.1.210.524
3ghuLDTAldose reductase1.1.1.210.523
3ghsLDTAldose reductase1.1.1.210.519
2pdn47DAldose reductase1.1.1.210.514
1frbZSTAldose reductase-related protein 2/0.510
2pdiZSTAldose reductase1.1.1.210.509
2duxZSTAldose reductase1.1.1.210.502
3ghtLDTAldose reductase1.1.1.210.501
2iqdLPAAldose reductase1.1.1.210.489
2inzOHPAldose reductase1.1.1.210.484
2pdj393Aldose reductase1.1.1.210.484
2pdq47DAldose reductase1.1.1.210.483
2duzZSTAldose reductase1.1.1.210.482
1zuaTOLAldo-keto reductase family 1 member B101.1.10.480
3ld5LDTAldose reductase1.1.1.210.480
2i17LDTAldose reductase1.1.1.210.476
1ah3TOLAldose reductase1.1.1.210.466
4ga8SBIAldo-keto reductase family 1 member B101.1.10.462
2f2kTGGAldose reductase1.1.1.210.461
2agtFIDAldose reductase1.1.1.210.455
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3n0hTOPDihydrofolate reductase1.5.1.30.453
4phlPILPhosphodiesterase/0.453
1h35R01Squalene--hopene cyclase4.2.1.1290.452
4araC56Acetylcholinesterase3.1.1.70.452
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.450
4j7hTRHPCZA361.3/0.450
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.447
2aovC2MHistamine N-methyltransferase2.1.1.80.445
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.444
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.443
4bj9UHBTankyrase-22.4.2.300.443
5d5aCAUBeta-2 adrenergic receptor/0.443
3qe2FMNNADPH--cytochrome P450 reductase/0.442
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.442
2xuqTZ4Acetylcholinesterase3.1.1.70.441
3ny8JRZBeta-2 adrenergic receptor/0.441