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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ftoTMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ftoTMPThymidylate synthase/1.000
3bgxTMPThymidylate synthase/0.585
1tysTMPThymidylate synthase/0.564
4iskUMPThymidylate synthase/0.559
1tduDURThymidylate synthase/0.555
1f28UMPThymidylate synthase2.1.1.450.554
1njbUMPThymidylate synthase/0.543
1jmiUMPThymidylate synthase/0.541
1dduDDUThymidylate synthase/0.540
2g8aUMPThymidylate synthase/0.527
1jmgUMPThymidylate synthase/0.526
2g89UMPThymidylate synthase/0.526
1tduCB3Thymidylate synthase/0.525
4einNOHThymidylate synthase2.1.1.450.520
4foxUMPThymidylate synthase ThyA/0.515
1jmhUMPThymidylate synthase/0.511
1tysDHFThymidylate synthase/0.509
1njcDCMThymidylate synthase/0.505
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.500
1bidUMPThymidylate synthase/0.499
1vzbUMPThymidylate synthase/0.499
3qj7UMPThymidylate synthase ThyA/0.499
4h0uUMPThymidylate synthase/0.499
1tsvUMPThymidylate synthase/0.497
1lcbTMPThymidylate synthase/0.496
1tsxUMPThymidylate synthase/0.494
1jmfUMPThymidylate synthase/0.492
2vf0F89Thymidylate synthase/0.492
1njdUMPThymidylate synthase/0.490
1vzaUMPThymidylate synthase/0.488
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.486
4dq1UMPThymidylate synthase/0.486
1njeDCMThymidylate synthase/0.484
1aobDDUThymidylate synthase/0.483
1bduDURThymidylate synthase/0.483
4eb4UMPThymidylate synthase2.1.1.450.482
2vetUMPThymidylate synthase/0.481
2g8dUMPThymidylate synthase/0.480
4irrUMPThymidylate synthase/0.479
2tsrUMPThymidylate synthase2.1.1.450.478
1bp0UMPThymidylate synthase/0.477
1b5dDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.476
2tdmUMPThymidylate synthase/0.474
1bp6UMPThymidylate synthase/0.472
1ci7UMPThymidylate synthase2.1.1.450.472
1tsyUMPThymidylate synthase/0.472
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.471
1njaDCMThymidylate synthase/0.469
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.468
2g86UMPThymidylate synthase/0.468
4kgmATPUncharacterized protein/0.467
4xsdUMPThymidylate synthase2.1.1.450.467
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.457
1thyUMPThymidylate synthase/0.456
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.455
3sufSUEPolyprotein/0.452
4e5oUMPThymidylate synthase2.1.1.450.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.449
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
1vf3GDNGlutathione S-transferase 32.5.1.180.447
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.443
1an5CB3Thymidylate synthase/0.442
1bpjUMPThymidylate synthase/0.442