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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2eq6FADDihydrolipoyl dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2eq6FADDihydrolipoyl dehydrogenase/1.000
2eq9FADDihydrolipoyl dehydrogenase/0.619
2eq8FADDihydrolipoyl dehydrogenase/0.602
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.568
1zx9FADMercuric reductase1.16.1.10.560
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.549
4jq9FADDihydrolipoyl dehydrogenase/0.549
1zk7FADMercuric reductase1.16.1.10.546
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.543
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.538
3ladFADDihydrolipoyl dehydrogenase/0.523
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.515
3urhFADDihydrolipoyl dehydrogenase/0.512
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.502
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.502
3ic9FADPutative dihydrolipoamide dehydrogenase/0.502
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.500
2r9zFADGlutathione amide reductase/0.490
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.483
2hqmFADGlutathione reductase1.8.1.70.482
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.477
3icrFADCoenzyme A disulfide reductase/0.477
2yquFADDihydrolipoyl dehydrogenase/0.472
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.470
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.464
1onfFADGlutathione reductase1.8.1.70.460
4j56FADThioredoxin reductase 21.8.1.90.456
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.455
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.455
1grhFADGlutathione reductase, mitochondrial1.8.1.70.454
1nhpFADNADH peroxidase1.11.1.10.454
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.454
3cgcFADCoenzyme A disulfide reductase/0.452
1grgFADGlutathione reductase, mitochondrial1.8.1.70.451
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.451
1bzlFADTrypanothione reductase1.8.1.120.448
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.448
3cgbFADCoenzyme A disulfide reductase/0.446
3ictFADCoenzyme A disulfide reductase/0.446
1greFADGlutathione reductase, mitochondrial1.8.1.70.445
1xdiFADNAD(P)H dehydrogenase (quinone)/0.444
2v6oFADThioredoxin glutathione reductase/0.443