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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c3u2TPPyruvate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c3u2TPPyruvate synthase/1.000
2c3oTPPPyruvate synthase/0.608
2uzaHTLPyruvate synthase/0.560
2pdaTPPPyruvate synthase/0.551
2c42TPPPyruvate synthase/0.541
2c3p1TPPyruvate synthase/0.538
2c3yHTLPyruvate synthase/0.512
1kekHTLPyruvate synthase/0.509
4ele31IDihydrofolate reductase/0.483
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.482
4o701QKBromodomain-containing protein 4/0.475
3och2MXDihydrofolate reductase1.5.1.30.473
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.472
1fwmCB3Thymidylate synthase/0.465
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.463
2z3uCRRCytochrome P450/0.460
2w6qOA5Biotin carboxylase6.3.4.140.458
4knzCB3Thymidylate synthase/0.458
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.454
3drcMTXDihydrofolate reductase1.5.1.30.453
3ft8MOJHeat shock protein HSP 90-alpha/0.452
4elg52JDihydrofolate reductase/0.452
1uy8PU5Heat shock protein HSP 90-alpha/0.451
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.451
2ihvTPPN(2)-(2-carboxyethyl)arginine synthase/0.451
3qwbNDPProbable quinone oxidoreductase1.6.5.50.451
1tdrMTXDihydrofolate reductase1.5.1.30.450
2e0nSAHPrecorrin-2 C20-methyltransferase/0.450
3jziJZLBiotin carboxylase6.3.4.140.450
1uydPU8Heat shock protein HSP 90-alpha/0.449
2hm9TRRDihydrofolate reductase1.5.1.30.449
3w6hAZMCarbonic anhydrase 14.2.1.10.449
1thnADPAnti-sigma F factor/0.448
3adaNADSubunit alpha of sarocosine oxidase/0.448
4nh82LCHeat shock protein HSP 90-alpha/0.448
4tl7ATPCircadian clock protein kinase KaiC2.7.11.10.448
1u1d181Uridine phosphorylase2.4.2.30.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.447
3av7KYNUncharacterized protein/0.447
3qdd94MHeat shock protein HSP 90-alpha/0.447
3zy3GDPGDP-fucose protein O-fucosyltransferase 12.4.1.2210.447
3zkyWT4Isopenicillin N synthase1.21.3.10.446
4fqsLYAThymidylate synthase ThyA/0.446
1cd2FOLDihydrofolate reductase1.5.1.30.445
3q44D50M1 family aminopeptidase3.4.110.445
3rtnRTNBeta-secretase 13.4.23.460.445
2w6zL21Biotin carboxylase6.3.4.140.444
3gc9B45Mitogen-activated protein kinase 112.7.11.240.444
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.444
4jlj1NMDeoxycytidine kinase2.7.1.740.444
1f4fTP3Thymidylate synthase/0.443
1obnASVIsopenicillin N synthase1.21.3.10.443
2ftoCB3Thymidylate synthase/0.443
2kceD16Thymidylate synthase/0.443
3kk6CELProstaglandin G/H synthase 11.14.99.10.443
3pe2E1BCasein kinase II subunit alpha2.7.11.10.443
4jva1ORcAMP-dependent protein kinase type II-beta regulatory subunit/0.443
4p66MTXDihydrofolate reductase/0.443
3c35KAIGlutamate receptor ionotropic, kainate 1/0.442
3pqbVGPPutative oxidoreductase/0.442
3r336MEDihydrofolate reductase1.5.1.30.442
4uyf73BBromodomain-containing protein 2/0.442
1f4gTP4Thymidylate synthase/0.441
1u1f183Uridine phosphorylase2.4.2.30.441
1vj3TABDihydrofolate reductase1.5.1.30.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
3jzfJZKBiotin carboxylase6.3.4.140.441
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
2v5aLZLBiotin carboxylase6.3.4.140.440
2x7hPFNProstaglandin reductase 310.440
3ix9MTXDihydrofolate reductase1.5.1.30.440