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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2acuNAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2acuNAPAldose reductase1.1.1.211.000
1az2NAPAldose reductase1.1.1.210.692
2iq0NAPAldose reductase1.1.1.210.681
1x96NAPAldose reductase1.1.1.210.641
2acqNAPAldose reductase1.1.1.210.634
2acsNAPAldose reductase1.1.1.210.621
2pf8NDPAldose reductase1.1.1.210.617
1adsNAPAldose reductase1.1.1.210.610
2pevNDPAldose reductase1.1.1.210.610
3q67NAPAldose reductase1.1.1.210.589
3v36NAPAldose reductase1.1.1.210.585
1x98NAPAldose reductase1.1.1.210.584
1z8aNAPAldose reductase1.1.1.210.575
2pfhNDPAldose reductase1.1.1.210.568
3q65NAPAldose reductase1.1.1.210.568
1ah4NAPAldose reductase1.1.1.210.566
2j8tNAPAldose reductase1.1.1.210.564
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.552
3o3rNAPAldose reductase-related protein 11.1.1.210.549
3qkzNAPAldose reductase-related protein 11.1.1.210.532
3h7rNAPAldo-keto reductase family 4 member C8/0.524
1s1rNAPAldo-keto reductase family 1 member C3/0.517
4pmjNAPPutative oxidoreductase/0.516
2hejNDPAldo-keto reductase family 1 member C211.1.10.515
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.513
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.511
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.508
4g5dNDPProstaglandin F synthase1.1.1.1880.503
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.497
1zgdNAPChalcone reductase/0.496
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.496
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.493
4dz5NAPAldo-keto reductase family 1 member C3/0.490
1c9wNAPAldose reductase-related protein 2/0.489
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.489
4xo7NAPAldo-keto reductase family 1 member C2/0.489
3wczNAPAldo-keto reductase AKR2E4/0.487
1pz1NAPGeneral stress protein 69/0.478
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.478
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.478
2hdjNDPAldo-keto reductase family 1 member C2/0.476
1ef3NAPAldose reductase1.1.1.210.473
2p5nNDPAldo-keto reductase family 1 member C211.1.10.470
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.469
4xzmNAPAldo-keto reductase family 1 member B101.1.10.468
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.465
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.463
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.462
4l1xNAPAldo-keto reductase family 1 member C2/0.462
1lqaNDPProtein tas/0.460
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4jtqNAPAldo-keto reductase family 1 member C2/0.457
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.453
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.453
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.452
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.451
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.450
1s1pNAPAldo-keto reductase family 1 member C3/0.447
4jq3NAPAldo-keto reductase family 1 member C2/0.446
2c91NAPAflatoxin B1 aldehyde reductase member 2/0.445
1vp5NAPOxidoreductase, aldo/keto reductase family/0.444