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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zxlJP1Enoyl-ACP reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zxlJP1Enoyl-ACP reductase/1.000
1zsnTN2Enoyl-ACP reductase/0.561
2foiJPAEnoyl-acyl carrier reductase/0.559
2ol4JPNEnoyl-ACP reductase/0.551
1nhgTCLEnoyl-ACP reductase/0.509
3nj8NJ8Enoyl-acyl carrier reductase/0.503
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.501
1zw1TN5Enoyl-ACP reductase/0.500
2op07PCEnoyl-ACP reductase/0.493
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
3f4bTCLEnoyl-acyl carrier protein reductase/0.483
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.482
1nnuTCTEnoyl-ACP reductase/0.481
3lt2FT3Enoyl-ACP reductase/0.476
2o2sTCLEnoyl-acyl carrier reductase/0.469
3lt0FT1Enoyl-ACP reductase/0.465
2o2yTCLEnoyl-ACP reductase/0.463
3lt1FT2Enoyl-ACP reductase/0.462
1uh5TCLEnoyl-ACP reductase/0.459
2vf0F89Thymidylate synthase/0.459
3am3TCLEnoyl-ACP reductase/0.457
4igeCHJEnoyl-acyl carrier reductase/0.457
1osvCHCBile acid receptor/0.456
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.456
3vt8YI3Vitamin D3 receptor/0.456
3lsyFT0Enoyl-ACP reductase/0.453
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.452
4at0FADPossible succinate dehydrogenase/0.450
4q71FADBifunctional protein PutA/0.449
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3sf6FDAGlutaryl-CoA dehydrogenase/0.445
4q73FADBifunctional protein PutA/0.444
4zm6ACON-acetyl-beta-D glucosaminidase/0.444
3up0D7SaceDAF-12/0.443
2xpuTDCTetracycline repressor protein class D/0.442
4ia7BIVVitamin D3 receptor A/0.442
4j7uNAPSepiapterin reductase1.1.1.1530.442
1heuNADAlcohol dehydrogenase E chain1.1.1.10.441
4q72FADBifunctional protein PutA/0.440