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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zx9FADMercuric reductase1.16.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zx9FADMercuric reductase1.16.1.11.000
1zk7FADMercuric reductase1.16.1.10.622
2eq9FADDihydrolipoyl dehydrogenase/0.526
4jq9FADDihydrolipoyl dehydrogenase/0.497
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.496
2eq8FADDihydrolipoyl dehydrogenase/0.491
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.490
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.488
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.485
3ladFADDihydrolipoyl dehydrogenase/0.483
3urhFADDihydrolipoyl dehydrogenase/0.481
2r9zFADGlutathione amide reductase/0.478
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.477
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.476
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.476
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.467
3grsFADGlutathione reductase, mitochondrial1.8.1.70.464
1grhFADGlutathione reductase, mitochondrial1.8.1.70.457
1greFADGlutathione reductase, mitochondrial1.8.1.70.454
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.454
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.452
1grgFADGlutathione reductase, mitochondrial1.8.1.70.451
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.451
3ic9FADPutative dihydrolipoamide dehydrogenase/0.450
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.449
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.449
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.448
2yquFADDihydrolipoyl dehydrogenase/0.446
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.444
2eq6FADDihydrolipoyl dehydrogenase/0.440
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.440
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.440