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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1z8aNAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1z8aNAPAldose reductase1.1.1.211.000
1x98NAPAldose reductase1.1.1.210.751
2acqNAPAldose reductase1.1.1.210.711
1x96NAPAldose reductase1.1.1.210.710
1adsNAPAldose reductase1.1.1.210.686
2iq0NAPAldose reductase1.1.1.210.672
2pf8NDPAldose reductase1.1.1.210.660
3q65NAPAldose reductase1.1.1.210.646
3v36NAPAldose reductase1.1.1.210.641
2pevNDPAldose reductase1.1.1.210.635
2pfhNDPAldose reductase1.1.1.210.632
3q67NAPAldose reductase1.1.1.210.625
2acsNAPAldose reductase1.1.1.210.602
1ah4NAPAldose reductase1.1.1.210.596
3qkzNAPAldose reductase-related protein 11.1.1.210.594
1az2NAPAldose reductase1.1.1.210.589
2j8tNAPAldose reductase1.1.1.210.589
2acuNAPAldose reductase1.1.1.210.571
3h7rNAPAldo-keto reductase family 4 member C8/0.566
3o3rNAPAldose reductase-related protein 11.1.1.210.563
1c9wNAPAldose reductase-related protein 2/0.548
4pmjNAPPutative oxidoreductase/0.541
2hejNDPAldo-keto reductase family 1 member C211.1.10.540
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.540
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.526
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.522
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.520
4g5dNDPProstaglandin F synthase1.1.1.1880.514
1lqaNDPProtein tas/0.512
1s1rNAPAldo-keto reductase family 1 member C3/0.509
4xo7NAPAldo-keto reductase family 1 member C2/0.499
2hdjNDPAldo-keto reductase family 1 member C2/0.495
1zgdNAPChalcone reductase/0.491
1ef3NAPAldose reductase1.1.1.210.489
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.488
4jtqNAPAldo-keto reductase family 1 member C2/0.488
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.486
5c7hNDPPutative oxidoreductase/0.486
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.484
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.483
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.482
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.480
1vp5NAPOxidoreductase, aldo/keto reductase family/0.479
4dz5NAPAldo-keto reductase family 1 member C3/0.477
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.476
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.472
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.472
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.469
4xzmNAPAldo-keto reductase family 1 member B101.1.10.468
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.465
3wczNAPAldo-keto reductase AKR2E4/0.464
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.463
2p5nNDPAldo-keto reductase family 1 member C211.1.10.462
4jq3NAPAldo-keto reductase family 1 member C2/0.460
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.457
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.454
4l1xNAPAldo-keto reductase family 1 member C2/0.452
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.450
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.450
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.450
2vdgNDPAldose reductase1.1.1.210.448
4xznNAPAldo-keto reductase family 1 member B101.1.10.447
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.443