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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xyyFMNFlavodoxin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xyyFMNFlavodoxin/1.000
3f6rFMNFlavodoxin/0.603
1bu5RBFFlavodoxin/0.574
5tgzFMNCannabinoid receptor 1/0.537
2fx2FMNFlavodoxin/0.531
1c7fFMNFlavodoxin/0.514
1akwFMNFlavodoxin/0.507
1xyvFMNFlavodoxin/0.506
1wsbFMNFlavodoxin/0.496
1j9gFMNFlavodoxin/0.488
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.487
5xraFMNCannabinoid receptor 1/0.487
1j9zFMNNADPH--cytochrome P450 reductase/0.485
1odcA8BAcetylcholinesterase3.1.1.70.482
3f90FMNFlavodoxin/0.479
1akrFMNFlavodoxin/0.478
1azlFMNFlavodoxin/0.476
2g1r3IGRenin3.4.23.150.475
3fznD7KBenzoylformate decarboxylase4.1.1.70.475
3kapFMNFlavodoxin/0.474
4fx2FMNFlavodoxin/0.474
1q84TZ4Acetylcholinesterase3.1.1.70.473
4araC56Acetylcholinesterase3.1.1.70.472
3fhxPXLPyridoxal kinase2.7.1.350.471
2po3T4K4-dehydrase/0.470
3ojxFMNNADPH--cytochrome P450 reductase/0.469
2jf0HBPAcetylcholinesterase3.1.1.70.468
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.468
3biy01KHistone acetyltransferase p300/0.468
1u65CP0Acetylcholinesterase3.1.1.70.467
5fx2FMNFlavodoxin/0.467
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.466
1zgbA1EAcetylcholinesterase3.1.1.70.465
3f6sFMNFlavodoxin/0.465
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.465
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.465
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.464
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.464
4y7cFMNNADPH--cytochrome P450 reductase/0.464
1krrACOGalactoside O-acetyltransferase2.3.1.180.463
2il2LIXRenin3.4.23.150.463
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.463
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.463
2bf4FMNNADPH--cytochrome P450 reductase/0.462
4b4w9L9Bifunctional protein FolD/0.462
3fktSIIBeta-secretase 13.4.23.460.461
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.459
1ja0FMNNADPH--cytochrome P450 reductase/0.459
2ha6SCKAcetylcholinesterase3.1.1.70.459
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.459
4b7zQ4QAcetylcholinesterase3.1.1.70.458
1obnASVIsopenicillin N synthase1.21.3.10.457
2xukTZ5Acetylcholinesterase3.1.1.70.457
2po7CHDFerrochelatase, mitochondrial4.99.1.10.456
3dv5BAVBeta-secretase 13.4.23.460.455
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1j8qFMNFlavodoxin/0.454
3k5c0BIBeta-secretase 13.4.23.460.454
4oxxFMNCindoxin/0.454
1hb1OCVIsopenicillin N synthase1.21.3.10.453
2xuoTZ4Acetylcholinesterase3.1.1.70.453
2cekN8TAcetylcholinesterase3.1.1.70.452
2ckmAA7Acetylcholinesterase3.1.1.70.452
2ejzSAHDiphthine synthase/0.452
1pqc444Oxysterols receptor LXR-beta/0.451
1hb3SCVIsopenicillin N synthase1.21.3.10.450
1ja1FMNNADPH--cytochrome P450 reductase/0.450
2wzySQXSoluble acetylcholine receptor/0.450
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.450
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.450
1rz1NADPhenol 2-hydroxylase component B/0.449
2xujTZ5Acetylcholinesterase3.1.1.70.449
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3junAKDPhenazine biosynthesis protein A/B/0.449
4c77N01Phenylacetone monooxygenase1.14.13.920.449
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.449
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.449
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.449
4kxjP34Nucleoprotein/0.448
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.447
1blzACVIsopenicillin N synthase1.21.3.10.446
2xuqTZ4Acetylcholinesterase3.1.1.70.446
4d04NAPPhenylacetone monooxygenase1.14.13.920.446
4lxa1YSBeta-secretase 13.4.23.460.446
5irnADPNucleotide binding oligomerization domain containing 2/0.446
1eveE20Acetylcholinesterase3.1.1.70.445
1zgcA2EAcetylcholinesterase3.1.1.70.445
4i0h1BLBeta-secretase 13.4.23.460.445
1qrpHH0Pepsin A-43.4.23.10.444
3bgxMEFThymidylate synthase/0.444
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.444
4nieNBHNuclear receptor ROR-gamma/0.444
1h22E10Acetylcholinesterase3.1.1.70.443
1mvtDTMDihydrofolate reductase1.5.1.30.443
2d29FADAcyl-CoA dehydrogenase/0.443
2ikuLIYRenin3.4.23.150.443
4m0f1YKAcetylcholinesterase3.1.1.70.443
4phlPILPhosphodiesterase/0.443
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.443
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.442
2g247IGRenin3.4.23.150.442
4lutDCSAlanine racemase/0.442
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.441
1ut6A8NAcetylcholinesterase3.1.1.70.441
3pqbVGPPutative oxidoreductase/0.441
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.441
5xr8FMNCannabinoid receptor 1/0.441
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.440
4dpf0LGBeta-secretase 13.4.23.460.440