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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1x98NAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1x98NAPAldose reductase1.1.1.211.000
1x96NAPAldose reductase1.1.1.210.873
1z8aNAPAldose reductase1.1.1.210.749
2j8tNAPAldose reductase1.1.1.210.739
2iq0NAPAldose reductase1.1.1.210.723
2acqNAPAldose reductase1.1.1.210.705
1az2NAPAldose reductase1.1.1.210.699
2acsNAPAldose reductase1.1.1.210.699
2pf8NDPAldose reductase1.1.1.210.651
3v36NAPAldose reductase1.1.1.210.648
2pfhNDPAldose reductase1.1.1.210.634
1ah4NAPAldose reductase1.1.1.210.614
3q67NAPAldose reductase1.1.1.210.609
2pevNDPAldose reductase1.1.1.210.608
3q65NAPAldose reductase1.1.1.210.608
2acuNAPAldose reductase1.1.1.210.593
1adsNAPAldose reductase1.1.1.210.587
3h7rNAPAldo-keto reductase family 4 member C8/0.582
3o3rNAPAldose reductase-related protein 11.1.1.210.575
1c9wNAPAldose reductase-related protein 2/0.546
2hejNDPAldo-keto reductase family 1 member C211.1.10.543
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.543
3qkzNAPAldose reductase-related protein 11.1.1.210.541
4g5dNDPProstaglandin F synthase1.1.1.1880.539
4pmjNAPPutative oxidoreductase/0.534
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.527
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.526
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.520
1zgdNAPChalcone reductase/0.501
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.501
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.500
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.500
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.492
5c7hNDPPutative oxidoreductase/0.492
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.490
2hdjNDPAldo-keto reductase family 1 member C2/0.490
4xo7NAPAldo-keto reductase family 1 member C2/0.490
4jtqNAPAldo-keto reductase family 1 member C2/0.488
1s1rNAPAldo-keto reductase family 1 member C3/0.486
2p5nNDPAldo-keto reductase family 1 member C211.1.10.484
4dz5NAPAldo-keto reductase family 1 member C3/0.483
3wczNAPAldo-keto reductase AKR2E4/0.481
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.480
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.478
1lqaNDPProtein tas/0.477
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.476
4l1xNAPAldo-keto reductase family 1 member C2/0.470
1vp5NAPOxidoreductase, aldo/keto reductase family/0.466
4jq3NAPAldo-keto reductase family 1 member C2/0.466
4xzmNAPAldo-keto reductase family 1 member B101.1.10.465
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.463
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.457
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.454
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.452
2vdgNDPAldose reductase1.1.1.210.451
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.450
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
1ef3NAPAldose reductase1.1.1.210.444
4xznNAPAldo-keto reductase family 1 member B101.1.10.444
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.443