sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1uys | H1L | Acetyl-CoA carboxylase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1uys | H1L | Acetyl-CoA carboxylase | / | 1.000 | |
| 1uyr | D1L | Acetyl-CoA carboxylase | / | 0.564 | |
| 4g2r | H1L | Probable propionyl-CoA carboxylase beta chain 6 | 6.4.1.3 | 0.536 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.489 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 3wag | TYD | Glycosyltransferase | / | 0.472 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.465 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.465 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.464 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.462 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.462 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.462 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.458 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.457 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.456 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.456 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.453 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.453 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.453 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.452 | |
| 5epv | ACP | Blue-light-activated histidine kinase | 2.7.13.3 | 0.452 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.449 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 5f8f | SFG | Possible transcriptional regulatory protein | / | 0.449 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3c1o | NAP | Eugenol synthase | / | 0.448 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.447 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.445 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.445 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.444 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 5dep | UD1 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.444 | |
| 1ghe | ACO | Acetyltransferase | 2.3.1 | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.443 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.442 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.441 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.441 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.441 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.441 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.440 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 |