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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1uwzTHUCytidine deaminase3.5.4.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1uwzTHUCytidine deaminase3.5.4.51.000
1jtkTHUCytidine deaminase3.5.4.50.842
1ux0THUCytidine deaminase3.5.4.50.647
1x8lOXRRetinol dehydratase/0.461
4kfj1R0Dihydrofolate reductase1.5.1.30.459
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1m9m6NINitric oxide synthase, endothelial1.14.13.390.456
2qimZEAClass 10 plant pathogenesis-related protein/0.454
1fmlRTLRetinol dehydratase/0.453
2y37A54Nitric oxide synthase, inducible1.14.13.390.451
3nksACJProtoporphyrinogen oxidase1.3.3.40.451
1m8h6NINitric oxide synthase, inducible1.14.13.390.450
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
4ap1NAPSteroid monooxygenase/0.449
4esoNAPPutative oxidoreductase/0.449
4bewACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
1m9k7NINitric oxide synthase, endothelial1.14.13.390.446
3eai328Nitric oxide synthase, inducible1.14.13.390.445
3fr5I4AFatty acid-binding protein, adipocyte/0.445
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.445
1touB1VFatty acid-binding protein, adipocyte/0.444
1uzwCDHIsopenicillin N synthase1.21.3.10.444
4lrrCF9Thymidylate synthase/0.444
4bfpSWYTankyrase-22.4.2.300.443
4fw05KJNitric oxide synthase, brain1.14.13.390.443
1hfqMOTDihydrofolate reductase1.5.1.30.442
2ejzSAHDiphthine synthase/0.442
1w06W05Isopenicillin N synthase1.21.3.10.440
3ihgVAKAklavinone 12-hydroxylase RdmE/0.440
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.440