Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tsdF89Thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tsdF89Thymidylate synthase/1.000
1tlcF89Thymidylate synthase/0.608
2vf0F89Thymidylate synthase/0.540
1jutLYDThymidylate synthase/0.493
1kceCB3Thymidylate synthase/0.490
1synF89Thymidylate synthase/0.490
1aiqCB3Thymidylate synthase/0.487
1f28F89Thymidylate synthase2.1.1.450.482
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.476
1kzjCB3Thymidylate synthase/0.472
1jtqLY3Thymidylate synthase/0.469
4knzCB3Thymidylate synthase/0.467
3bgxMEFThymidylate synthase/0.466
1nceCB3Thymidylate synthase/0.463
3bhlTHGThymidylate synthase/0.455
1dnaCB3Thymidylate synthase/0.452
2bbqPFGThymidylate synthase/0.445
1axwMTXThymidylate synthase/0.444
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
1trgCB3Thymidylate synthase/0.443
4fogC2FThymidylate synthase ThyA/0.441