sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 1.000 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.651 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.608 | |
| 1cq8 | PY6 | Aspartate aminotransferase | 2.6.1.1 | 0.587 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.565 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.562 | |
| 1maq | PGU | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.558 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.554 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.531 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.528 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.518 | |
| 1map | KET | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.490 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.480 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1asc | NPL | Aspartate aminotransferase | 2.6.1.1 | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.457 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.455 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ppj | ANY | Cytochrome b | / | 0.451 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.451 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 2bxo | OPB | Serum albumin | / | 0.447 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.446 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.445 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.444 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.443 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.443 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.441 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 |