sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1tez | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1tez | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 1.000 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.645 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.487 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.479 | |
| 1wc0 | APC | Adenylate cyclase | / | 0.477 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.470 | |
| 1wc6 | TAT | Adenylate cyclase | / | 0.467 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.467 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 3qa2 | XNA | Ketohexokinase | / | 0.464 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.462 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.461 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.460 | |
| 3q92 | XNB | Ketohexokinase | / | 0.459 | |
| 4d9f | DCS | D-cysteine desulfhydrase | / | 0.459 | |
| 1wc5 | APC | Adenylate cyclase | / | 0.457 | |
| 3x0a | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.457 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 1hk5 | T44 | Serum albumin | / | 0.456 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.455 | |
| 1kws | UGA | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 | / | 0.455 | |
| 1wc1 | TAT | Adenylate cyclase | / | 0.455 | |
| 1lol | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.454 | |
| 3k3b | ADP | Kinesin-like protein KIF11 | / | 0.454 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.452 | |
| 3eel | 53T | Uncharacterized protein | / | 0.451 | |
| 3m0e | ATP | Transcriptional regulator (NtrC family) | / | 0.450 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4fa6 | 0TA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.449 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.449 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.448 | |
| 1zao | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.447 | |
| 4bec | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.447 | |
| 3chw | ATP | Major actin | / | 0.446 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4tv3 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.446 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.445 | |
| 3cse | N22 | Uncharacterized protein | / | 0.445 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.444 | |
| 2qkr | IXM | Cdc2-like CDK2/CDC28 like protein kinase | / | 0.444 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1v0p | PVB | Cell division control protein 2 homolog | 2.7.11.22 | 0.442 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.442 | |
| 4oa9 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.442 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3ztx | ZTX | Aurora kinase B-A | 2.7.11.1 | 0.441 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.441 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.441 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.440 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.440 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.440 | |
| 4gnc | ASO | Regucalcin | 3.1.1.17 | 0.440 |