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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sa4JANProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sa4JANProtein farnesyltransferase subunit beta2.5.1.581.000
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.785
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.770
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.768
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.729
1s63778Protein farnesyltransferase subunit beta2.5.1.580.687
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.684
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.636
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.636
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.611
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.610
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.606
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.581
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.578
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.572
3q7fED2Uncharacterized protein/0.525
3sfy3FYUncharacterized protein/0.525
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.521
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.517
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.517
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.505
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.498
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.490
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.483
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.474
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.473
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.469
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.467
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.464