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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1pqc444Oxysterols receptor LXR-beta

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1pqc444Oxysterols receptor LXR-beta/1.000
1pq944BOxysterols receptor LXR-beta/0.659
4dk70KSOxysterols receptor LXR-beta/0.553
1upw444Oxysterols receptor LXR-beta/0.538
1p8dCO1Oxysterols receptor LXR-beta/0.536
2aclL05Oxysterols receptor LXR-alpha/0.497
1pq6965Oxysterols receptor LXR-beta/0.484
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.468
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.466
4bb3KKAIsopenicillin N synthase1.21.3.10.462
1obnASVIsopenicillin N synthase1.21.3.10.460
4kbyC2EStimulator of interferon genes protein/0.460
2iyaZIOOleandomycin glycosyltransferase/0.459
4phlPILPhosphodiesterase/0.459
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.458
3up0D7SaceDAF-12/0.457
1qiqACCIsopenicillin N synthase1.21.3.10.456
2nq8ZIDEnoyl-ACP reductase/0.455
3gw9VNILanosterol 14-alpha-demethylase/0.455
3ipq965Oxysterols receptor LXR-alpha/0.455
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
2vbpVB1Isopenicillin N synthase1.21.3.10.453
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.453
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.453
1oc1ASVIsopenicillin N synthase1.21.3.10.451
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.451
4q0kGA3Phytohormone-binding protein/0.451
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.450
1k7l544Peroxisome proliferator-activated receptor alpha/0.449
1qjfACSIsopenicillin N synthase1.21.3.10.448
2bu9HFVIsopenicillin N synthase1.21.3.10.448
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.447
3nx4NAPPutative oxidoreductase/0.447
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.447
4iah1DXAlr2278 protein/0.447
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.446
1uzwCDHIsopenicillin N synthase1.21.3.10.446
2rgoFADAlpha-Glycerophosphate Oxidase/0.446
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
1hb3SCVIsopenicillin N synthase1.21.3.10.445
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
2y6fM9FIsopenicillin N synthase1.21.3.10.445
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2iviACWIsopenicillin N synthase1.21.3.10.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.443
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
4yfy0FXVioF/0.443
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.442
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4iae1DXAlr2278 protein/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
5dp2NAPCurF/0.442
2y60M8FIsopenicillin N synthase1.21.3.10.441
2f3815MAldo-keto reductase family 1 member C3/0.440