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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1mdlRMNMandelate racemase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1mdlRMNMandelate racemase/1.000
1mdlSMNMandelate racemase/0.786
1dtnAPGMandelate racemase/0.520
2ydxSTLMethionine adenosyltransferase 2 subunit beta/0.465
4u0oMTALipoyl synthase 2/0.465
1i59ANPChemotaxis protein CheA2.7.13.30.459
3ntgD72Prostaglandin G/H synthase 21.14.99.10.459
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.458
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.456
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.452
2xpwOTCTetracycline repressor protein class D/0.448
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.447
2w03ADNAcsD/0.447
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.447
3buzTADIota toxin component Ia/0.447
3hf3FMNChromate reductase/0.447
3smkCW714-3-3 protein sigma/0.446
1st0GTGm7GpppX diphosphatase3.6.1.590.445
3rqkH4BNitric oxide synthase, brain1.14.13.390.444
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
4pytFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.442
1tw2ERTCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.441
2zxgS23Aminopeptidase N3.4.11.20.441
4ucu8HCDNA ligase/0.441
3d5wADPSerine/threonine-protein kinase PLK/0.440