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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.35

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.351.000
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.665
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.638
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.630
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.581
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.558
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.497
4pzdNAD3-Hydroxyacyl-CoA dehydrogenase/0.487
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.485
1phgMYTCamphor 5-monooxygenase1.14.15.10.468
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.463
1y0s331Peroxisome proliferator-activated receptor delta/0.462
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1f4fTP3Thymidylate synthase/0.461
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1jioDEB6-deoxyerythronolide B hydroxylase/0.458
1k6pXN3Gag-Pol polyprotein3.4.23.160.458
1xddAAYIntegrin alpha-L/0.456
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.453
3p3zP3ZPutative cytochrome P450/0.453
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3mdvCL6Cholesterol 24-hydroxylase/0.451
3vt7VDXVitamin D3 receptor/0.451
3opdHIEHeat shock protein 83/0.450
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.450
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.448
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1bygSTUTyrosine-protein kinase CSK/0.446
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.446
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4l8u9AZSerum albumin/0.446
4q71FADBifunctional protein PutA/0.446
4q72FADBifunctional protein PutA/0.446
2iviACWIsopenicillin N synthase1.21.3.10.444
3atzFMNProstaglandin F2a synthase/0.444
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.444
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1fmlRTLRetinol dehydratase/0.443
2ath3EAPeroxisome proliferator-activated receptor gamma/0.443
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3v9v21LPeroxisome proliferator-activated receptor gamma/0.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
3bc3OPTCathepsin L13.4.22.150.441
3gggNADPrephenate dehydrogenase/0.441
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.441
1dhiMTXDihydrofolate reductase1.5.1.30.440
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2rkvZBATrichothecene 3-O-acetyltransferase/0.440
4e5yNDPGDP-L-fucose synthase1.1.1.2710.440
4enhFVXCholesterol 24-hydroxylase/0.440