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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.21.000
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.574
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.515
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.511
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.499
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.498
1nhhANPDNA mismatch repair protein MutL/0.495
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.477
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.476
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.464
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.458
4ivgANPTNF receptor-associated protein 1/0.453
4prvADPDNA gyrase subunit B/0.452
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.450
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.450
1ie4T44Transthyretin/0.449
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2henADPEphrin type-B receptor 22.7.10.10.447
4xcjADPHeat shock cognate 90 kDa protein/0.447
3oriAGSSerine/threonine protein kinase/0.446
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.446
4ix5ANPUncharacterized protein/0.445
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.445
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
3frqERYErythromycin resistance repressor protein/0.444
1bsvNDPGDP-L-fucose synthase/0.443
3nszANPCasein kinase II subunit alpha2.7.11.10.443
4k33ACPFibroblast growth factor receptor 32.7.10.10.443
3a3bRBFLumazine protein/0.442
3mdvCL6Cholesterol 24-hydroxylase/0.442
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
1k6pXN3Gag-Pol polyprotein3.4.23.160.441
3c4wATPRhodopsin kinase/0.441
3qj5022Alcohol dehydrogenase class-31.1.1.10.441
4oauADP2-5A-dependent ribonuclease3.1.260.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4wudANPDNA gyrase subunit B/0.440