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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1isjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1isjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.61.000
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.541
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.497
2j7cIDEBeta-glucosidase A3.2.1.210.473
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.473
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.472
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.471
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.470
3uyk0CXProbable NDP-rhamnosyltransferase/0.469
2v57PRLTetR family transcriptional regulator/0.468
3ocw3AMLipoprotein E/0.468
4arbC57Acetylcholinesterase3.1.1.70.467
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.464
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.464
3rm8RM8Acidic mammalian chitinase3.2.1.140.462
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2bjsACVIsopenicillin N synthase1.21.3.10.461
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.461
2pb1NFGGlucan 1,3-beta-glucosidase/0.460
2pdh47DAldose reductase1.1.1.210.458
4dbw511Aldo-keto reductase family 1 member C3/0.458
1ry0PG2Aldo-keto reductase family 1 member C3/0.457
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.457
3ugrIMNAldo-keto reductase family 1 member C3/0.457
4au7SAHHistone-lysine N-methyltransferase KMT5C2.1.1.430.457
2f3815MAldo-keto reductase family 1 member C3/0.456
3htjETEbrA repressor/0.456
4jvlESTEstrogen sulfotransferase2.8.2.40.456
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.454
2b82ADNClass B acid phosphatase3.1.3.20.453
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.453
5cc9DDFDihydrofolate reductase1.5.1.30.453
2pdfZSTAldose reductase1.1.1.210.452
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.452
3hthPRLEbrA repressor/0.452
4bjcRPBTankyrase-22.4.2.300.452
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.450
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.449
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.449
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.448
2cdcNAPGlucose 1-dehydrogenase/0.448
2j7dGI1Beta-glucosidase A3.2.1.210.448
3ocx2AMLipoprotein E/0.448
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.448
3zwoG2QADP-ribosyl cyclase/cyclic ADP-ribose hydrolase3.2.2.60.448
4jpg1OXPyruvate kinase PKM2.7.1.400.448
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.447
3dz6M8ES-adenosylmethionine decarboxylase proenzyme4.1.1.500.447
3h0wN8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.447
3arvSAUChitinase A/0.446
3bm4ADVADP-sugar pyrophosphatase3.6.1.130.446
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3dz7O8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.446
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.446
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.445
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.445
2yczI32Beta-1 adrenergic receptor/0.445
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
1w6rGNTAcetylcholinesterase3.1.1.70.444
2aotSAHHistamine N-methyltransferase2.1.1.80.444
2fzbTOLAldose reductase1.1.1.210.444
2hzqSTRApolipoprotein D/0.444
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.444
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2x9vTMQPteridine reductase/0.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.442
2xugTZ4Acetylcholinesterase3.1.1.70.442
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3iu9T07Methionine aminopeptidase 2/0.442
1xf0ASDAldo-keto reductase family 1 member C3/0.441
2d06ESTSulfotransferase 1A12.8.2.10.441
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1srfMTBStreptavidin/0.440
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.440
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.440
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.440
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.440
5cxv0HKMuscarinic acetylcholine receptor M1/0.440