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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ihiIU5Aldo-keto reductase family 1 member C2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ihiIU5Aldo-keto reductase family 1 member C2/1.000
4jtrIBPAldo-keto reductase family 1 member C2/0.624
4jtrIZPAldo-keto reductase family 1 member C2/0.614
4jqaID8Aldo-keto reductase family 1 member C2/0.601
4jq3ZOMAldo-keto reductase family 1 member C2/0.598
4xo7ASDAldo-keto reductase family 1 member C2/0.598
4jtqFLPAldo-keto reductase family 1 member C2/0.593
4jq2SUZAldo-keto reductase family 1 member C2/0.586
2ipjFFAAldo-keto reductase family 1 member C2/0.584
4jq1NPSAldo-keto reductase family 1 member C2/0.566
4l1xSTRAldo-keto reductase family 1 member C2/0.562
1mrqSTRAldo-keto reductase family 1 member C1/0.561
4jq4IMNAldo-keto reductase family 1 member C2/0.494
4dbs0HVAldo-keto reductase family 1 member C3/0.489
3zkyWT4Isopenicillin N synthase1.21.3.10.473
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.472
1h35R01Squalene--hopene cyclase4.2.1.1290.471
1o6qR17Squalene--hopene cyclase4.2.1.1290.471
2f3815MAldo-keto reductase family 1 member C3/0.471
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.469
1fmlRTLRetinol dehydratase/0.466
1lkeDOGBilin-binding protein/0.466
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.466
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.464
1h36R88Squalene--hopene cyclase4.2.1.1290.463
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.462
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.461
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.461
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.459
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.458
1pqc444Oxysterols receptor LXR-beta/0.457
4xwtU5PRibonuclease J/0.457
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.456
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.455
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.455
1x8lOXRRetinol dehydratase/0.455
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.454
3v0o4GWHisto-blood group ABO system transferase/0.452
3r6iJMSAldo-keto reductase family 1 member C3/0.451
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.451
4n1gCEIObelin/0.451
1g63FMNEpidermin decarboxylase4.1.10.450
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
1zq5E04Aldo-keto reductase family 1 member C3/0.450
2qimZEAClass 10 plant pathogenesis-related protein/0.450
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.449
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.448
2ea4F79Methionine aminopeptidase 2/0.447
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.447
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.447
4bfuZVUPantothenate kinase2.7.1.330.447
4u140HKMuscarinic acetylcholine receptor M3/0.447
1p8dCO1Oxysterols receptor LXR-beta/0.446
1pq944BOxysterols receptor LXR-beta/0.446
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.446
3f3y4OABile salt sulfotransferase2.8.2.140.446
3mj4URMUDP-galactopyranose mutase/0.446
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4li61XOTankyrase-12.4.2.300.446
1lnmDTXBilin-binding protein/0.445
1ry0PG2Aldo-keto reductase family 1 member C3/0.445
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.445
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.445
3bl7DD1m7GpppX diphosphatase3.6.1.590.444
3c1oNAPEugenol synthase/0.444
3c3xNAPEugenol synthase 11.1.1.3180.444
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.444
4jyzATPGlutamine--tRNA ligase6.1.1.180.444
4psbGA3Cytokinin-specific binding protein/0.444
1u2rSO1Elongation factor 2/0.443
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4bfxZVXPantothenate kinase2.7.1.330.443
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4bfzZVZPantothenate kinase2.7.1.330.442
1t40ID5Aldose reductase1.1.1.210.441
2r8oT5XTransketolase 1/0.441
2rehFADNitroalkane oxidase1.7.3.10.441
2zsdCOAPantothenate kinase2.7.1.330.441
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3r94FLRAldo-keto reductase family 1 member C3/0.441
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.441
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.441
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.441
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.441
2xujTZ5Acetylcholinesterase3.1.1.70.440
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.440