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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gxfFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gxfFADTrypanothione reductase1.8.1.121.000
4nevFADTrypanothione reductase/0.616
2wbaFADTrypanothione reductase1.8.1.120.585
1bzlFADTrypanothione reductase1.8.1.120.574
2jk6FADTrypanothione reductase/0.574
4dnaFADProbable glutathione reductase/0.566
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.558
1febFADTrypanothione reductase1.8.1.120.553
1tytFADTrypanothione reductase1.8.1.120.549
2wp5FADTrypanothione reductase/0.548
2hqmFADGlutathione reductase1.8.1.70.546
1fecFADTrypanothione reductase1.8.1.120.544
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.540
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.537
4la1FADThioredoxin glutathione reductase/0.528
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.523
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.520
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.516
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.515
1gerFADGlutathione reductase1.8.1.70.514
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.511
1typFADTrypanothione reductase1.8.1.120.510
2r9zFADGlutathione amide reductase/0.508
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.502
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.488
2eq6FADDihydrolipoyl dehydrogenase/0.480
4j57FADThioredoxin reductase 21.8.1.90.479
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.471
1feaFADTrypanothione reductase1.8.1.120.470
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.465
3ladFADDihydrolipoyl dehydrogenase/0.465
2eq9FADDihydrolipoyl dehydrogenase/0.461
2yquFADDihydrolipoyl dehydrogenase/0.461
3urhFADDihydrolipoyl dehydrogenase/0.461
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.460
1zx9FADMercuric reductase1.16.1.10.456
2w0hFADTrypanothione reductase/0.455
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.453
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.450
2eq8FADDihydrolipoyl dehydrogenase/0.448
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.447
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.445
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2wowFADTrypanothione reductase/0.441