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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fkwPURAdenosine deaminase3.5.4.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fkwPURAdenosine deaminase3.5.4.41.000
2adaHPRAdenosine deaminase3.5.4.40.662
1fkxPRHAdenosine deaminase3.5.4.40.642
1qxlFR8Adenosine deaminase3.5.4.40.532
1uioHPRAdenosine deaminase3.5.4.40.527
1umlFR4Adenosine deaminase3.5.4.40.527
1ndzFR5Adenosine deaminase3.5.4.40.516
1v7aFRCAdenosine deaminase3.5.4.40.507
1a4lDCFAdenosine deaminase3.5.4.40.500
1v79FR7Adenosine deaminase3.5.4.40.498
1wxyFRKAdenosine deaminase3.5.4.40.497
1o5rFR9Adenosine deaminase3.5.4.40.496
1ndyFR3Adenosine deaminase3.5.4.40.488
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.481
3p9tTCLRepressor/0.476
1dcyI3NPhospholipase A2, membrane associated/0.470
1db56INPhospholipase A2, membrane associated/0.466
2vagV25Dual specificity protein kinase CLK12.7.12.10.466
2z7gEH9Adenosine deaminase3.5.4.40.462
3emlZMAAdenosine receptor A2a/0.462
4i2pG73Gag-Pol polyprotein2.7.7.490.461
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
4ez8DHFThymidylate synthase2.1.1.450.458
1db48INPhospholipase A2, membrane associated/0.456
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.455
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.454
3u8dU8DPhospholipase A2, membrane associated/0.453
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.453
1vyrFMNPentaerythritol tetranitrate reductase/0.452
2zd1T27Gag-Pol polyprotein2.7.7.490.451
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3p5sAVUCD38 molecule/0.450
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
1h35R01Squalene--hopene cyclase4.2.1.1290.448
1kt3RTLRetinol-binding protein 4/0.448
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
2ze2T27Gag-Pol polyprotein2.7.7.490.446
4gevCB3Thymidylate synthase/0.446
2zb45OPProstaglandin reductase 21.3.1.480.445
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.445
1hvyD16Thymidylate synthase2.1.1.450.444
3up0D7SaceDAF-12/0.444
4ddrMMVDihydrofolate reductase1.5.1.30.444
1cqp803Integrin alpha-L/0.443
1swpBTNStreptavidin/0.443
2iyaZIOOleandomycin glycosyltransferase/0.443
3pd3A3TThreonine--tRNA ligase6.1.1.30.443
1c3eGARPhosphoribosylglycinamide formyltransferase/0.442
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1nq7ARLNuclear receptor ROR-beta/0.441
1x8lOXRRetinol dehydratase/0.441
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3ujlA8SAbscisic acid receptor PYL2/0.441
4o8aFADBifunctional protein PutA1.2.1.880.441
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.440
2w71L23Biotin carboxylase6.3.4.140.440
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3vzdUULSphingosine kinase 12.7.1.910.440