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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.100

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1001.000
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.583
1ipeNDPTropinone reductase 21.1.1.2360.579
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.576
1oaaNAPSepiapterin reductase1.1.1.1530.555
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.553
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.546
4j7uNAPSepiapterin reductase1.1.1.1530.546
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.534
5idwNAPShort-chain dehydrogenase/reductase SDR/0.534
1ae1NAPTropinone reductase 1/0.532
4hwkNAPSepiapterin reductase1.1.1.1530.526
4j7xNAPSepiapterin reductase1.1.1.1530.525
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.524
1wntNAPL-xylulose reductase1.1.1.100.519
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.519
1xg5NAPDehydrogenase/reductase SDR family member 11/0.516
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.515
1snyNAPLD36273p/0.514
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.512
3p19NDPPutative blue fluorescent protein/0.512
1pr9NAPL-xylulose reductase1.1.1.100.506
2dteNAIGlucose 1-dehydrogenase related protein/0.504
3wdsNADNADH-dependent quinuclidinone reductase/0.502
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.502
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.501
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.500
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.500
3d3wNAPL-xylulose reductase1.1.1.100.496
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.495
1x7gNAPPutative ketoacyl reductase1.3.10.494
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.491
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.488
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.486
2bd0NAPSepiapterin reductase/0.486
2wsbNADGalactitol dehydrogenase/0.486
4bmvNAPShort-chain dehydrogenase/0.484
4fn4NADShort chain dehydrogenase/0.484
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.483
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.483
4gh5NADShort-chain dehydrogenase/reductase SDR/0.482
1n5dNDPCarbonyl reductase [NADPH] 1/0.481
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.479
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.478
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.478
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.478
5jydNADShort chain dehydrogenase/0.478
3a4vNADNDP-sugar epimerase/0.477
3s55NADPutative short-chain dehydrogenase/reductase/0.477
4yaiNAIC alpha-dehydrogenase/0.477
3sx2NADUncharacterized protein/0.476
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.476
4qecNAPElxO/0.476
1iy8NADLevodione reductase/0.475
2yutNAPPutative short-chain oxidoreductase/0.475
3gy0NAPNAD(P)-dependent oxidoreductase/0.475
3w8eNAD3-hydroxybutyrate dehydrogenase/0.475
1rwbNADGlucose 1-dehydrogenase1.1.1.470.474
2jahNDPClavaldehyde dehydrogenase/0.474
5jlaNADPutative short-chain dehydrogenase/reductase/0.473
3l77NJPShort-chain alcohol dehydrogenase/0.472
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.472
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.471
2wdzNADGalactitol dehydrogenase/0.470
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.469
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.467
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.467
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
4yagNAIC alpha-dehydrogenase/0.466
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.465
4dc1NDPPutative ketoacyl reductase1.3.10.465
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.464
5lc1NADL-threonine 3-dehydrogenase/0.464
2yy7NADL-threonine dehydrogenase/0.463
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.463
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.462
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.461
3sjuNDPKeto reductase/0.461
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.460
1sbyNADAlcohol dehydrogenase1.1.1.10.459
3tn7NJPShort-chain alcohol dehydrogenase/0.459
1w4zNAPPutative ketoacyl reductase1.3.10.458
3toxNAPPutative oxidoreductase/0.458
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.458
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.456
3rj5NADAlcohol dehydrogenase1.1.1.10.456
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.456
1x7hNDPPutative ketoacyl reductase1.3.10.455
1xkqNDPUncharacterized protein/0.455
3a1nNADNDP-sugar epimerase/0.455
3qrwNDPPutative ketoacyl reductase1.3.10.455
3rj9NADAlcohol dehydrogenase1.1.1.10.453
3ak4NADNADH-dependent quinuclidinone reductase/0.452
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4esoNAPPutative oxidoreductase/0.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.450
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.450
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.449
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3vdqNAD3-hydroxybutyrate dehydrogenase/0.446
4qedNAPElxO/0.446
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.443
3u4cNDPNADPH-dependent reductase BacG/0.442